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Issue 10 (4) 2011 pp. 507-512

Joanna Suliburska1, Paweł Bogdański2, Barbara Chiniewicz1

1Poznań University of Life Sciences
2
University of Medical Science in Poznań

The influence of selected hypotensive drugs on the bioavailability of minerals from buckwheat groats in vitro enzymatic digestion

Abstract

 

Background. The mineral status in hypertensive patients may be affected by hypotensive drugs. The aim of this study was to estimate the influence of hypotensive drugs (angiotensine converting enzyme inhibitors (ACE-I), b-blockers, Ca-antagonists, diuretics) on the potential bioavailability of magnesium, iron, zinc and copper from buckwheat groats in vitro enzymatic digestion.
Material and methods. The degree of release of magnesium, iron, zinc and copper from buckwheat groats was determined with and without (the control sample) an addition of hypotensive drugs. Four antihypertensive drugs in one dose (one tablet per sample) were analysed: metocard (a β-blocker), cardilopin (a Ca-antagonist), apo-perindox (ACE-I) and indapen (a diuretic). The samples were subjected to enzymatic digestion under in vitro conditions. The content of minerals in buckwheat groats before and after enzymatic digestion was determined by flame atomic absorption spectrometry (AAS).
Results. It was found that cardilopin (amlodipine) and indapen (indapamide) significantly increased the release of zinc from groats. The degree of release of magnesium was higher and the release of iron was lower in samples with apo-perindox (perindopril) than in the control group. The release of copper was significantly decreased by indapen (indapamid).
Conclusions. Amlodipine, perindopril and indapamide affected the release of magnesium, iron, zinc and copper from buckwheat groats in vitro enzymatic digestion.

 

Keywords: food-drug interaction, minerals bioavailability

For citation:

MLA Suliburska, Joanna, et al. "The influence of selected hypotensive drugs on the bioavailability of minerals from buckwheat groats in vitro enzymatic digestion." Acta Sci.Pol. Technol. Aliment. 10.4 (2011): 507-512.
APA Suliburska J., Bogdański P., Chiniewicz B. (2011). The influence of selected hypotensive drugs on the bioavailability of minerals from buckwheat groats in vitro enzymatic digestion. Acta Sci.Pol. Technol. Aliment. 10 (4), 507-512
ISO 690 SULIBURSKA, Joanna, BOGDAńSKI, Paweł, CHINIEWICZ, Barbara. The influence of selected hypotensive drugs on the bioavailability of minerals from buckwheat groats in vitro enzymatic digestion. Acta Sci.Pol. Technol. Aliment., 2011, 10.4: 507-512.