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Issue 13 (1) 2014 pp. 103-110

Joanna Suliburska1, Paweł Bogdański2, Zbigniew Krejpcio1

1Department of Human Nutrition and Hygiene, Poznań University of Life Sciences, Poland
2
Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznań University of Medical Sciences, Poland

Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment

Abstract

Introduction. One side effect of antihypertensive drugs is their impact on nutritional status and metabolism. The purpose of this study was to assess the nutritional and biochemical parameters in spontaneously hypertensive rats following treatment with antihypertensive drugs.
Material and methods. The experiment was performed on 50 male spontaneously hypertensive rats (SHR), which were assigned to fi ve groups: control (C), with perindopril (PR), with metoprolol (MT), with indapamide (ID), and with amlodipine (AM). All rats were provided ad libitum standard diet (with or without drugs) and distilled water. After 45 days, the animals were weighed and killed. Liver, kidney, heart, spleen, pancreas, and blood samples were collected. Concentrations of glucose, cholesterol, triglycerides, and albumin were assayed in serum. Morphology parameters, such as white blood cell, red blood cell, hematocrit, and lymphocyte counts were measured in the blood. Blood pressure was measured using a tail-cuff plethysmograph.
Results. The results obtained indicate that the hypotensive drugs under investigation had no effect on the selected nutritional parameters. Perindopril signifi cantly decreased the relative mass of the heart and amlodipine markedly decreased the relative mass of the pancreas. A markedly higher concentration of glucose in the group with indapamid, and a signifi cantly lower concentration of triglycerides in the group with metoprolol, were observed. Indapamide and amlodipine markedly increased the value of red blood cells and hematocrit in the blood of SHR.
Conclusions. Long-term therapy with antihypertension drugs may infl uence tissue mass and biochemical and morphological status in the body.

Keywords: antihypertensive drugs, nutritional status, glucose, lipids, hematocrit, spontaneously hypertensive rats
pub/.pdf Full text available in english in Adobe Acrobat format:
http://www.food.actapol.net/issue1/volume/9_1_2014.pdf

http://dx.doi.org/10.17306/J.AFS.2014.1.9

For citation:

MLA Suliburska, Joanna, et al. "Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment." Acta Sci.Pol. Technol. Aliment. 13.1 (2014): 103-110. http://dx.doi.org/10.17306/J.AFS.2014.1.9
APA Suliburska J., Bogdański P., Krejpcio Z. (2014). Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment. Acta Sci.Pol. Technol. Aliment. 13 (1), 103-110 http://dx.doi.org/10.17306/J.AFS.2014.1.9
ISO 690 SULIBURSKA, Joanna, BOGDAńSKI, Paweł, KREJPCIO, Zbigniew. Evaluation of nutritional and biochemical parameters in spontaneously hypertensive rats following antihypertensive treatment. Acta Sci.Pol. Technol. Aliment., 2014, 13.1: 103-110. http://dx.doi.org/10.17306/J.AFS.2014.1.9