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Skalny A. A., Tinkov A. A., Medvedeva Y. S., Alchinova I. B., Karganov M. Y., Skalny A. V., Nikonorov A. A., 2015. Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes. Acta Sci.Pol. Technol. Aliment. 14 (3), 269-276

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original articleIssue 14 (3) 2015 pp. 269-276

Andrey A. Skalny1,2, Alexey A. Tinkov2,3,4, Yulia S. Medvedeva5, Irina B. Alchinova5, Mikhail Y. Karganov5, Anatoly V. Skalny2,3,5, Alexandr A. Nikonorov4

1Federal State Scientific Institution Institute of Toxicology, Federal Medico-Biological Agency, St. Petersburg, Russia
2
Russian Society of Trace Elements in Medicine, ANO Centre for Biotic Medicine, Moscow, Russia
3
Laboratory of Biotechnology and Applied Bioelementology, Yaroslavl State University, Russia
4
Department of Biochemistry, Orenburg State Medical University, Russia
5
Laboratory of Physicochemical and Ecological Pathophysiology, Institute of General Pathology and Pathophysiology, Moscov, Russia
6
Institute of Bioelementology Russian Satellite Centre of Trace Element - Institute for UNESCO, Orenburg State University, Russia

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Abstract

Background. A significant association between Zn and Se homeostasis exists. At the same time, data on the influence of zinc supplementation on selenium distribution in organs and tissues seem to be absent. Therefore, the primary objective of the current study is to investigate the influence of zinc asparaginate supplementation on zinc and selenium distribution and serum superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in Wistar rats.
Material and methods. 36 rats were used in the experiment. The duration of the experiment was 7 and 14 days in the first and second series, respectively. The rats in Group I were used as the control ones. Animals in Groups II and III daily obtained zinc asparaginate (ZnA) in the doses of 5 and 15 mg/kg weight, respectively. Zinc and selenium content in liver, kidneys, heart, muscle, serum and hair was assessed using inductively coupled plasma mass spectrometry. Serum SOD and GPx activity was analysed spectrophotometrically using Randox kits.
Results. Intragastric administration of zinc asparaginate significantly increased liver, kidney, and serum zinc content without affecting skeletal and cardiac muscle levels. Zinc supplementation also stimulated selenium retention in the rats’ organs. Moreover, a significant positive correlation between zinc and selenium content was observed. Finally, zinc asparaginate treatment has been shown to modulate serum GPx but not SOD activity.
Conclusion. The obtained data indicate that zinc-induced increase in GPx activity may be mediated through modulation of selenium status. However, future studies are required to estimate the exact mechanisms of zinc and selenium interplay.

Keywords: zinc asparaginate, selenium, superoxide dismutase, glutathione peroxidase
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http://dx.doi.org/10.17306/J.AFS.2015.3.28

For citation:

MLA Skalny, Andrey A., et al. "Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes." Acta Sci.Pol. Technol. Aliment. 14.3 (2015): 269-276. http://dx.doi.org/10.17306/J.AFS.2015.3.28
APA Skalny A. A., Tinkov A. A., Medvedeva Y. S., Alchinova I. B., Karganov M. Y., Skalny A. V., Nikonorov A. A. (2015). Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes. Acta Sci.Pol. Technol. Aliment. 14 (3), 269-276 http://dx.doi.org/10.17306/J.AFS.2015.3.28
ISO 690 SKALNY, Andrey A., et al. Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes. Acta Sci.Pol. Technol. Aliment., 2015, 14.3: 269-276. http://dx.doi.org/10.17306/J.AFS.2015.3.28