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Mądry E., Chudzicka-Strugała I., GrabańskaMartyńska K., Malikowska K., Grebowiec P., Lisowska A., Bogdańsk, P., Walkowiak J., 2016. Twelve weeks CLA supplementation decreases the hip circumference in overweight and obese women. A double-blind, randomized, placebo-controlled trial. Acta Sci.Pol. Technol. Aliment. 15 (1), 107-113

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original articleIssue 15 (1) 2016 pp. 107-113

Edyta Mądry1, Izabela Chudzicka-Strugała2, Katarzyna Grabańska-Martyńska3, Klaudia Malikowska4, Philip Grebowiec4, Aleksandra Lisowska4, Paweł Bogdański5, Jarosław Walkowiak4

1Department of Physiology, Poznan University of Medical Sciences, Poland
2
Department of Medical Microbiology, Poznan University of Medical Sciences, Poland
3
Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Poland
4
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland
5
Department of Education and Obesity Treatment and Metabolic Disorders, Poznań University of Medical Sciences, Poland

Twelve weeks CLA supplementation decreases the hip circumference in overweight and obese women. A double-blind, randomized, placebo-controlled trial

Abstract

Background. Conjugated linoleic acid (CLA) reduces body weight (BW), body fat mass (BFM), and increases or maintains lean body mass in animals. However, the results concerning the effect of CLA on weight reduction in humans are contradictory. The present study aimed to evaluate the effect of CLA supplementation on the BW and anthropometric parameters (waist and hip circumferences) in overweight and obese adult women.
Material and methods. A total of 74 subjects (BMI: 28–42 kg/m2) were included in a double blind, placebocontrolled trial. Subjects were randomized into two groups, those supplemented with either 3.0 g/d CLA or with placebo (sunflower oil) for 12 weeks.
Results. CLA significantly decreased the hip circumferences compared to placebo (p = 0.016209), but had no effect on body weight, BMI, or waist circumference. The number of subjects with a reduction in hip circumference in the CLA group was significantly larger compared to that in the placebo group (p = 0.0017;  NNT= 2.65; CI [6.27–1.685]).
Conclusions. In conclusion, our findings do not support the hypothesis that 12 weeks CLA supplementation, as dosed in the present study, is effective for body weight reduction in overweight and obese women. However, its local action in decreasing the hip circumference seems to be encouraging and suggests that CLA may represent an attractive dietary supplement.

Keywords: CLA, placebo, hip circumference, waist circumference, body weight, BMI
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http://dx.doi.org/10.17306/J.AFS.2016.1.11

For citation:

MLA Mądry, Edyta, et al. "Twelve weeks CLA supplementation decreases the hip circumference in overweight and obese women. A double-blind, randomized, placebo-controlled trial." Acta Sci.Pol. Technol. Aliment. 15.1 (2016): 107-113. http://dx.doi.org/10.17306/J.AFS.2016.1.11
APA Mądry E., Chudzicka-Strugała I., GrabańskaMartyńska K., Malikowska K., Grebowiec P., Lisowska A., Bogdańsk, P., Walkowiak J. (2016). Twelve weeks CLA supplementation decreases the hip circumference in overweight and obese women. A double-blind, randomized, placebo-controlled trial. Acta Sci.Pol. Technol. Aliment. 15 (1), 107-113 http://dx.doi.org/10.17306/J.AFS.2016.1.11
ISO 690 MąDRY, Edyta, et al. Twelve weeks CLA supplementation decreases the hip circumference in overweight and obese women. A double-blind, randomized, placebo-controlled trial. Acta Sci.Pol. Technol. Aliment., 2016, 15.1: 107-113. http://dx.doi.org/10.17306/J.AFS.2016.1.11