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original articleIssue 15 (2) 2016 pp. 221-225

Renata Mozrzymas1, Monika Duś-Żuchowska2, Łukasz Kałużny2, Ewa Wenska-Chyży2, Jarosław Walkowiak2

1Voivodeship Hospital, Wrocław, Poland
2
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland

Phenylketonuria is not a risk factor for changes of inflammation status as assessed by interleukin 6 and interleukin 8 concentrations

Abstract

Background. High oxidative stress and a reduced potential for free radical scavenging in phenylketonuria (PKU) patients, a phenomenon confirmed in a few studies, may lead to systemic chronic inflammation. The aim of this study was to compare the inflammation status, as assessed by interleukin 6 and interleukin 8 concentrations, in patients with PKU and in healthy controls.
Material and methods. Twenty patients with classical PKU, aged 18–34 years and under dietary control, were enrolled in the study. The control group comprised of 20 healthy subjects matched for age and sex. Interleukin 6 and 8 levels were measured by enzyme-linked immunosorbent assay (ELISA) kits in all study participants.
Results. IL-6 concentrations in the study group ranged from 0.74 pg/ml to 1.34 pg/ml. No significant differences were found between IL-6 concentration between the study group and the control group (p = 0.989). IL-8 concentrations ranged from 17.56 pg/ml to 20.87 pg/ml. The obtained results of IL-8 levels did not differ significantly between the study group and control group (p = 0.192). No significant correlation was observed between Phe blood levels and IL-6 or IL-8 concentrations in the study group (ρ respectively: –0.225, 0.177). In a multivariate analysis, neither IL-6 nor IL-8 concentrations were correlated with sex, age, BMI and Phe levels.
Conclusions. Phenylketonuria is not a risk factor for changes of inflammation status as assessed by IL-6 and IL-8 concentrations.

Keywords: phenylketonuria, inflammation, interleukin 6, interleukin 8
pub/.pdf Full text available in english in Adobe Acrobat format:
http://www.food.actapol.net/issue2/volume/11_2_2016.pdf

http://dx.doi.org/10.17306/J.AFS.2016.2.22

For citation:

MLA Mozrzymas, Renata, et al. "Phenylketonuria is not a risk factor for changes of inflammation status as assessed by interleukin 6 and interleukin 8 concentrations." Acta Sci.Pol. Technol. Aliment. 15.2 (2016): 221-225. http://dx.doi.org/10.17306/J.AFS.2016.2.22
APA Mozrzymas R., Duś-Żuchowska M., Kałużny Ł., Wenska-Chyży E., Walkowiak J. (2016). Phenylketonuria is not a risk factor for changes of inflammation status as assessed by interleukin 6 and interleukin 8 concentrations. Acta Sci.Pol. Technol. Aliment. 15 (2), 221-225 http://dx.doi.org/10.17306/J.AFS.2016.2.22
ISO 690 MOZRZYMAS, Renata, et al. Phenylketonuria is not a risk factor for changes of inflammation status as assessed by interleukin 6 and interleukin 8 concentrations. Acta Sci.Pol. Technol. Aliment., 2016, 15.2: 221-225. http://dx.doi.org/10.17306/J.AFS.2016.2.22