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Sapiejka E., Krzyżanowska P., Walkowiak D., Wenska-Chyży E., Szczepanik M., Cofta S., Pogorzelski A., Skorupa W., Walkowiak J. , 2017. Vitamin A status and its determinants in patients with cystic fibrosis. Acta Sci.Pol. Technol. Aliment. 16 (3), 345-354

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original articleIssue 16 (3) 2017 pp. 345-354

Ewa Sapiejka1, Patrycja Krzyżanowska2, Dariusz Walkowiak3, Ewa Wenska-Chyży2, Mariusz Szczepanik2, Szczepan Cofta4, Andrzej Pogorzelski5, Wojciech Skorupa6, Jarosław Walkowiak2

1The Specialist Centre for Medical Care of Mother and Child, Gdańsk-Oliwa, Poland
2
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland
3
Department of Organization and Management in Health Care, Poznan University of Medical Sciences, Poland
4
University Hospital of Lord?s Transfiguration, Partner of Poznan University of Medical Sciences, Poland
5
Department of Pulmonology and Cystic Fibrosis, Institute of Tuberculosis and Lung Diseases, Rabka-Zdrój, Poland
6
I Department of Lung Diseases, National Institute for Tuberculosis and Lung Diseases, Warsaw, Poland

Vitamin A status and its determinants in patients with cystic fibrosis

Abstract

Background. Routine administration of vitamin A, recommended in CF patients, can help to prevent its deficiency. However, high vitamin A supplementation may lead to its excessive level and possible toxicity. Therefore, the aim of the present study was to assess the status of vitamin A and the determinants of its body resources in CF patients.

Material and methods. In 196 CF patients aged from 4 months to 47 years, the following parameters  were analysed: nutritional status (standardized body weight and height, serum albumin concentration) and clinical expression of disease (lung function − spirometry; biochemical markers of liver function − ALT, AST, GGT; respiratory tract colonization by Pseudomonas aeruginosa; diabetes; cirrhosis, non-cirrhotic liver disease; exocrine pancreatic function − fecal elastase-1 concentration; blood clotting –  INR  and  vitamin  A supplementation).

Results. Median vitamin A concentration in the study group was 383.0 ng/ml (1st–3rd quartile: 316.5–457.0). Vitamin A deficiency was found in 32 (16.3%) subjects studied. Vitamin A concentrations above the reference range were observed only in 3 (1.5%) CF patients. CF patients with vitamin A deficiency were significantly older and had lower values of FEV1 compared to CF subjects with normal vitamin A status. Moreover, vitamin A deficiency occurred more frequently in CF patients with diabetes, Pseudomonas aeruginosa colo- nization, worse lung function and in those without vitamin A supplementation. However, in multiple linear regression analyses, none of the independent variables was documented to be important for predicting vita- min A status.

Conclusions. Vitamin A body resources in CF patients are mostly normal. Moreover, there are no good de- terminants of vitamin A status in these patients. Further studies targeted at exploring potential toxicity and deficiencies of vitamin A in CF patients are needed.

Keywords: retinol, fat-soluble vitamins, pancreatic disease, liver cirrhosis, high-performance liquid chromatography
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http://dx.doi.org/10.17306/J.AFS.0473

For citation:

MLA Sapiejka, Ewa, et al. "Vitamin A status and its determinants in patients with cystic fibrosis." Acta Sci.Pol. Technol. Aliment. 16.3 (2017): 345-354. http://dx.doi.org/10.17306/J.AFS.0473
APA Sapiejka E., Krzyżanowska P., Walkowiak D., Wenska-Chyży E., Szczepanik M., Cofta S., Pogorzelski A., Skorupa W., Walkowiak J. (2017). Vitamin A status and its determinants in patients with cystic fibrosis. Acta Sci.Pol. Technol. Aliment. 16 (3), 345-354 http://dx.doi.org/10.17306/J.AFS.0473
ISO 690 SAPIEJKA, Ewa, et al. Vitamin A status and its determinants in patients with cystic fibrosis. Acta Sci.Pol. Technol. Aliment., 2017, 16.3: 345-354. http://dx.doi.org/10.17306/J.AFS.0473