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Issue 8 (1) 2009 pp. 63-69

Aleksandra Duda-Chodak1, Dorota Markiewicz1, Piotr Pierzchalski2

1University of Agriculture in Krakow
2
Jagiellonian University in Krakow

The effect of quercetin, chlorogenic acid and epigallocatechin on proliferation of Caco-2 cells

Abstract

Dietary polyphenols are considered beneficial because of their potential protective role in the pathogenesis of chronic diseases associated to oxidative stress. However, many of these effects may depend on the concentration of the antioxidants used. The aim of the study was to evaluate the effect of quercetin, chlorogenic acid and epigallocatechin on proliferation of human colon adenocarcinoma cells Caco-2. Caco-2 cells were treated with different concentrations (25, 50, 100, 200, and 400 μM in DMSO) of antioxidants and the proliferation was assayed by MTT method. The results of the study indicated that chlorogenic acid and quercetin enhanced Caco-2 cells proliferation in time- and concentration-dependent manner. In contrary, epigallocatechin exhibit inhibitory influence, particularly significant at concentration ≥ 200 μM.

Keywords: human colon adenocarcinoma Caco-2 cells, oxidative stress, antioxidants, polyphenols, proliferation
pub/.pdf Full text available in english in Adobe Acrobat format:
http://www.food.actapol.net/issue1/volume/6_1_2009.pdf

For citation:

MLA Duda-Chodak, Aleksandra, et al. "The effect of quercetin, chlorogenic acid and epigallocatechin on proliferation of Caco-2 cells." Acta Sci.Pol. Technol. Aliment. 8.1 (2009): 63-69.
APA Duda-Chodak A., Markiewicz D., Pierzchalski P. (2009). The effect of quercetin, chlorogenic acid and epigallocatechin on proliferation of Caco-2 cells. Acta Sci.Pol. Technol. Aliment. 8 (1), 63-69
ISO 690 DUDA-CHODAK, Aleksandra, MARKIEWICZ, Dorota, PIERZCHALSKI, Piotr. The effect of quercetin, chlorogenic acid and epigallocatechin on proliferation of Caco-2 cells. Acta Sci.Pol. Technol. Aliment., 2009, 8.1: 63-69.