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Issue 9 (2) 2010 pp. 237-241

Mieczysław Walczak1, Beata Pawlus1,2, Andrzej Kędzia3, Jarosław Walkowiak3,4

1Pomeranian Medical University in Szczecin
2
Holy Family of Gynecology and Obstetrics in Warsaw
3
Poznań University of Medical Sciences
4
Poznań University of Life Sciences

Active synthesis of epidermal growth factor in human mammary glands

Abstract

Background. Human milk contains considerable number of growth factors, including epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1). There are no data comparing the EGF and IGF-1 levels in the serum and milk of breast-feeding women. Therefore, the aim of our study was to assess a possible relationship between the concentrations of these growth factors.

Material and methods. Thirty-nine women in child-birth were included in the study.
All women provided blood and milk samples during the first six hours after delivery. EGF (by immunoenzymatic method) and IGF-1 (by radioimmunossay method) concentrations were measured in both media.
Results. EGF breast milk concentrations ranged from 3.18 to 4.51 ng/ml and on average were significantly higher (p < 0.0001) than those found in the women’s serum (from 0.02 to 0.13 ng/ml). The opposite distribution was found for IGF-1 levels. Its milk concentrations ranged from 8.8 to 61.9 ng/ml and on average were significantly lower (p < 0.0001) than the serum concentrations (from 192.6 to 595.3 ng/ml). No correlation was found between the serum and milk concentrations of both growth factors.

Conclusion. EGF seems to be synthesized locally in mammary glands, whereas IGF-1 probably permeates into the milk from the vascular bed.

 

Keywords: epidermal growth factor, insulin-like growth factor-1, human milk, serum
pub/.pdf Full text available in english in Adobe Acrobat format:
http://www.food.actapol.net/issue2/volume/10_2_2010.pdf

For citation:

MLA Walczak, Mieczysław, et al. "Active synthesis of epidermal growth factor in human mammary glands." Acta Sci.Pol. Technol. Aliment. 9.2 (2010): 237-241.
APA Walczak M., Pawlus B., Kędzia A., Walkowiak J. (2010). Active synthesis of epidermal growth factor in human mammary glands. Acta Sci.Pol. Technol. Aliment. 9 (2), 237-241
ISO 690 WALCZAK, Mieczysław, et al. Active synthesis of epidermal growth factor in human mammary glands. Acta Sci.Pol. Technol. Aliment., 2010, 9.2: 237-241.