Issue 9 (2) 2010 pp. 237-241
Mieczysław Walczak1, Beata Pawlus1,2, Andrzej Kędzia3, Jarosław Walkowiak3,4
2Holy Family of Gynecology and Obstetrics in Warsaw
3Poznań University of Medical Sciences
4Poznań University of Life Sciences
ACTIVE SYNTHESIS OF EPIDERMAL GROWTH FACTOR IN HUMAN MAMMARY GLANDS
Background. Human milk contains considerable number of growth factors, including epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1). There are no data comparing the EGF and IGF-1 levels in the serum and milk of breast-feeding women. Therefore, the aim of our study was to assess a possible relationship between the concentrations of these growth factors.
All women provided blood and milk samples during the first six hours after delivery. EGF (by immunoenzymatic method) and IGF-1 (by radioimmunossay method) concentrations were measured in both media.
Conclusion. EGF seems to be synthesized locally in mammary glands, whereas IGF-1 probably permeates into the milk from the vascular bed.
Keywords: epidermal growth factor, insulin-like growth factor-1, human milk, serum
Walczak M., Pawlus B., Kędzia A., Walkowiak J., 2010. Active synthesis of epidermal growth factor in human mammary glands. Acta Sci.Pol., Technol. Aliment. 9 (2), 237-241