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Issue 9 (2) 2010 pp. 237-241

Mieczysław Walczak1, Beata Pawlus1,2, Andrzej Kędzia3, Jarosław Walkowiak3,4

1Pomeranian Medical University in Szczecin
2
Holy Family of Gynecology and Obstetrics in Warsaw
3
Poznań University of Medical Sciences
4
Poznań University of Life Sciences

Active synthesis of epidermal growth factor in human mammary glands

Abstract:

Background. Human milk contains considerable number of growth factors, including epidermal growth factor (EGF) and insulin-like growth factor-1 (IGF-1). There are no data comparing the EGF and IGF-1 levels in the serum and milk of breast-feeding women. Therefore, the aim of our study was to assess a possible relationship between the concentrations of these growth factors.

Material and methods. Thirty-nine women in child-birth were included in the study.
All women provided blood and milk samples during the first six hours after delivery. EGF (by immunoenzymatic method) and IGF-1 (by radioimmunossay method) concentrations were measured in both media.
Results. EGF breast milk concentrations ranged from 3.18 to 4.51 ng/ml and on average were significantly higher (p < 0.0001) than those found in the women’s serum (from 0.02 to 0.13 ng/ml). The opposite distribution was found for IGF-1 levels. Its milk concentrations ranged from 8.8 to 61.9 ng/ml and on average were significantly lower (p < 0.0001) than the serum concentrations (from 192.6 to 595.3 ng/ml). No correlation was found between the serum and milk concentrations of both growth factors.

Conclusion. EGF seems to be synthesized locally in mammary glands, whereas IGF-1 probably permeates into the milk from the vascular bed.

 

pub/.pdf Full text available in english in Adobe Acrobat format:
http://www.food.actapol.net/issue2/volume/10_2_2010.pdf
Keywords: epidermal growth factor, insulin-like growth factor-1, human milk, serum
For citation:

MLA Walczak, Mieczysław, et al. "Active synthesis of epidermal growth factor in human mammary glands." Acta Sci.Pol. Technol. Aliment. 9.2 (2010): 237-241.
APA Walczak M., Pawlus B., Kędzia A., Walkowiak J. (2010). Active synthesis of epidermal growth factor in human mammary glands. Acta Sci.Pol. Technol. Aliment. 9 (2), 237-241
ISO 690 WALCZAK, Mieczysław, et al. Active synthesis of epidermal growth factor in human mammary glands. Acta Sci.Pol. Technol. Aliment., 2010, 9.2: 237-241.
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Streszczenie w języku polskim:
http://www.food.actapol.net/tom9/zeszyt2/abstrakt-10.html