Acta Scientiarum Polonorum Technologia Alimentaria Wydawnictwo uniwersytetu Przyrodniczego w Poznaniu 1644-0730 1898-9594

ORIGINAL_ARTICLE 361-370 en 2017 16 4 Norma F. Santos-Sánchez Raúl Salas-Coronado Rogelio Valadez-Blanco Beatriz Hernández-Carlos Paula C. Guadarrama-Mendoza Adlercreutz, H., Höckerstedt, K., Bannwart, C., Bloigu, S., Hämäläinen, E., Fotsis, T., Ollus, A. (1987). Effect of dietary components, including lignans and phytoes- trogens, on enterohepatic circulation and liver metabo- lism of estrogens and on sex hormone binding globulin (SHBG). J. Steroid Biochem., 27, 1135-44. https://doi.org/10.1016/0022-4731(87)90200-7 Ahmad, M., Baba, W. N., Wani, T. A., Gani, A., Gani, A., Shah, U., ..., Masoodi, F. A. (2015). Effect of green tea powder on thermal, rheological and functional properties of wheat flour and physical, nutraceutical and sensory analysis of cookies. J. Food Sci. Technol., 52(9), 5799-5807. http://dx.doi.org/10.1007/s13197-014-1701-3 Amin, A., Hamza, A. A., Bajbouj, K., Ashraf, S. S., Daoud,S. (2011). Saffron: A potential candidate for a novel anti- cancer drug against hepatocellular carcinoma. Hepatol- ogy, 54(3), 857-867. https://doi.org/10.1002/hep.24433 Amorati, R., Foti, M. C., Valgimigli, L. (2013). Antioxidant activity of essential oils. J. Agric. Food Chem., 61(46),10835-10847. http://doi.org/10.1021/jf403496k Baines, D., Seal, R. (2012). Natural food additives, ingredients and flavourings, Woodhead Publishing, Cambridge, UK. Bishayee, A., Háznagy-Radnai, E., Mbimba, T., Sipos, P., Morazzoni, P., Darvesh, A. S., ..., Hohmann, J. (2010). Anthocyanin-rich black currant extract suppresses the growth of human hepatocellular carcinoma cells. Natu- ral Prod. Commun., 5(10), 1613-1618. Black, C. D., Herring, M. P., Hurley, D. J., O'Connor, P. J. (2010). Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise. J. Pain, 11(9), 894-903. https://doi.org/10.1016/j.jpain.2009.12.013 Bown, D. (2001). New encyclopedia of herbs and their uses. London, UK: Dorling Kindersley, London, Herb Society of America. Carocho, M., Barreiro, M. F., Morales, P., Ferreira, I. C. F.R. (2014). Adding molecules to Food, pros and cons:A review of synthetic and natural food additives. Compr. Rev. Food Sci. Food Safety, 13(4), 377-399. https://doi.org/10.1111/1541-4337.12065 Carocho, M., Ferreira, I. C. F. R. (2013). The role of phe- nolic compounds in the fight against cáncer - a review. AntiCancer Agents Med. Chem., 13(8), 1236-1258.PMID: 23796249. Chainani-Wu, N. (2003). Safety and anti-inflammatory ac- tivity of curcumin: A component of tumeric (Curcuma longa). J. Altern. Compl. Med., 9(1), 161-168. https://doi.org/10.1089/107555303321223035 Chen, X., Anderson, J. J. B. (2001). Isoflavones inhibit pro- liferation of ovarian cancer cells in vitro via an estro- gen receptor-dependent pathway. Nutr. Cancer, 41(1-2), 165-171. https://doi.org/10.1080/01635581.2001.9680628 Choe, E., Min, D. B. (2009). Mechanisms of antioxidants in the oxidation of foods. Compr. Rev. Food Sci. Food Safe- ty, 8(4), 345-358. http://dx.doi.org/10.1111/j.1541-4337.2009.00085.x Conforti, F., Statti, G. A., Menichini, F. (2007). Chemical and biological variability of hot pepper fruits (Capsi- cum annuum var. acuminatum L.) in relation to matu- rity stage. Food Chem., 102(4), 1096-1104. https://doi.org/10.1016/j.foodchem.2006.06.047 de Pascual-Teresa, S. (2014). Molecular mechanisms in- volved in the cardiovascular and neuroprotective effects of anthocyanins. Arch. Biochem. Biophys., 559, 68-74. https://doi.org/10.1016/j.abb.2014.04.012 de Raadt, P., Wirtz, S., Vos, E., Verhagen, H. (2015). Short review of extracts of Rosemary as a food additive. Eur. J. Nutr. Food Safety, 5(3), 126-137. https://doi. org/10.9734/EJNFS/2015/10404 El-Ghorab, A. H., Nauman, M., Anjum, F. M., Hussain, S., Nadeem, M. (2010). A comparative study on chemical composition and antioxidant activity of ginger (Zin- giber officinale) and cumin (Cuminum cyminum). J. Agric. Food Chem., 58(14), 8231-8237. https://doi.org/10.1021/jf101202x Faizal, P., Kumar, R. S., Augusti, K. T. (2009). A study on the hypoglycemic and hypolipidemic effects of an ayur- vedic drug Rajanyamalakadi in diabetic pacients. Indian J. Clin. Biochem., 24(1), 82-87. https://doi.org/10.1007/s12291-009-0014-1 Gutteridge, J. M. C., Halliwell, B. (1994). Antioxidants in nutrition, health and disease. Oxford, UK: Oxford Uni- versity Press. Higdon, J. V., Frei, B. (2003). Tea catechins and polyphe- nols: Health effects, metabolism, and antioxidant func- tions. Critic. Rev. Food Sci. Nutr., 43(1), 89-143. https://doi.org/10.1080/10408690390826464 Jamwal, A., Kumar, S., Bhat, Z. F., Kumar, A., Kaur, S. (2015). The quality and storage stability of chick- en patties prepared with different additives. Nutr. Food Sci., 45(5), 728-739. https://doi.org/10.1108/ NFS-01-2015-0009 Jensen, S., Ostdal, H., Skibsted, L. H., Thybo, A. K. (2011). Antioxidants and shelf life of whoe wheat bread. J. Cereal Sci., 53, 291-297. https://doi.org/10.1016/j. jcs.2011.01.010 Jiang, H., Xie, Z., Koo, H. J., McLaughlin, S.P., Timmer- mann, B. N., Gang, D. R. (2006). Metabolic profiling and phylogenetic analysis of medicinal Zingiber spe- cies: Tools for authentication of ginger (Zingiber offi- cinale Rosc.). Phytochemistry, 67, (15), 1673-1685. https://doi.org/10.1016/j.phytochem.2005.08.001 Jolad, S. D., Lantz, R. C., Solyom, A. M., Chen, G. J., Bates,R. B., Timmermann, B. N. (2004). Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production. Phytochemistry, 65(13), 1937-1954. https://doi.org/10.1016/j.phytochem.2004.06.008 Jongberg, S., Trngren, M. A., Gunvig, A., Skibsted, L. H., Lund, M. N. (2013). Effect of green tea or rosemary ex- tract on protein oxidation in Bologna type sausages pre- pared from oxidatively stressed pork. Meat Sci., 93(3), 538-546. https://doi.org/10.1016/j.meatsci.2012.11.005 Jordán, M. J., Castillo, J., Baón, S., Martínez-Conesa, C., Sotomayor, J. A. (2014). Relevance of the carnosic acid/carnosol ratio for the level of rosemary diterpene transfer and for improving lamb meat antioxidant status.Food Chem., 151, 212-218. https://doi.org/10.1016/j.foodchem.2013.11.068 Karimi, E., Oskoueian, E., Hendra, R., Jaafar, H. Z. E. (2010). Evaluation of Crocus sativus L. stigma phenolic and flavonoid compounds and its antioxidant activity. Molecules, 15(9), 6244-6256. https://doi.org/10.3390/ molecules15096244 Kisnk, Y. F. M., Elsheshetawy, H. E. (2013). Effect of gin- ger powder on the mayonnaise oxidative stability, rheo- logical measurements, and sensory characteristics. Ann. Agric. Sci., 58, 213-220. http://dx.doi.org/10.1016/j.aoas.2013.07.016 Lee, A. H., Su, D., Pasalich, M., Tang, L., Binns, C. W., Qiu,L. (2014): Soy and isoflavone intake associated with re- duced risk of ovarian cancer in southern Chinese wom- en. Nutr. Res., 34(4), 302-307. https://doi.org/10.1016/j.nutres.2014.02.005 Manzocco, L., Anese, M., Nicoli, M. C. (1998). Antioxi- dant properties of tea extracts as affected by processing. LWT - Food Sci. Technol., 31(7-8), 694-698. http://doi.org/10.1006/fstl.1998.0491 Martínez-Tomé, M., Jiménez, A. M., Ruggieri, S., Frega, N., Strabbioli, R., Murcia, M. A. (2001). Antioxidant properties of mediterranean spices compared with common food additives. J. Food Prot., 64(9), 1412-1419. https://doi.org/10.4315/0362-028X-64.9.1412 Materska, M. (2014). Bioactive phenolics of fresh and freeze-dried sweet and semi-spicy pepper fruits (Cap- sicum annuum L.). J. Funct. Foods, 7, 269-277. https://doi.org/10.1016/j.jff.2014.02.002 McCarthy, T. L., Kerry, J. P., Kerry, J. F., Lynch, P. B., Buck- ley, D. J. (2001). Evaluation of the antioxidant potential of natural food/plant extracts as compared with synthetic antioxidants and vitamin E in raw and cooked pork patties. Meat Sci., 57(1), 45-52. https://doi.org/10.1016/S0309-1740(00)00129-7 Mitsumoto, M., O-Grady, M. N., Kerry, J. P., Buckley, D. J. (2005). Addition of tea catechins and vitamin C on sensory evaluation, colour and lipid stability during chilled storage in cooked or raw beef and chicken patties. Meat Sci., 69(4), 773-779. https://doi.org/10.1016/j.meatsci.2004.11.010 Moghaddasi, M. S., Kashani, H. H. (2012). Ginger (Zin- giber officinale): A review. J. Med. Plants Res., 6(26), 4255-4258. Morouti, N., Panagiotakus, D. B. (2013). Soy food con- sumption and breast cancer. Maturitas, 76(2), 118-122. https://doi.org/10.1016/j.maturitas.2013.07.006 Müller, W., Fiebich, B. L., Stratz, T. (2006). New treatment options using 5-HT3 receptor antagonists in rheumatic diseases. Curr. Topics Med. Chem., 6(18), 2035-2042. https://doi.org/10.2174/156802606778522122 Najgebauer-Lejko, D. (2014). Effect of green tea supplemen- tation on the microbiological, antioxidant, and sensory properties of probiotic milks. Dairy Sci. Technol., 94(4), 327-339. https://doi.org/10.1007/s13594-014-0165-6 Nissen, L. R., Byrne, D. V., Bertelsen, G., Skibsted, L. H. (2004). The antioxidative activity of plant extracts in cooked pork patties as evaluated by descriptive sensory profiling and chemical analysis. Meat Sci., 68, 485-495. https://doi.org/10.1016/j.meatsci.2004.05.004 Ortu-o, J., Serrano, R., Jordán, M. J., Baón, S. (2014). Shelf life of meat from lambs given essential oil-free rosemary extract containing carnosic acid plus carnosol at 200 or 400 mg kg-1. Meat Sci., 96, 1452-1459. https:// doi.org/10.1016/j.meatsci.2013.11.021 Park, E. J., Pizzuto, J. M. (2002). Botanicals in cancer chem- oprevention. Cancer Metast. Rev., 21(3-4), 231-255. Pelissero, C., Lenczowski, M. J., Chinzi, D., Davail-Cuisset, B., Sumpter, J. P., Fostier, A. (1996). Effects of flavonoids on aromatase activity, an in vitro study. J. Steroid Biochem. Molec. Biol., 57(3-4), 215-23. https://doi.org/10.1016/0960-0760(95)00261-8 Ponce, A. G., Roura, S. I., del Valle, C. E., Moreira, M. R. (2008). Antimicrobial and antioxidant activities of edible coatings enriched with natural plant extracts: In vitro and in vivo studies. Postharv. Biol. Technol., 49, 294- 300. https://doi.org/10.1016/j.postharvbio.2008.02.013 Salas-Coronado, R., Hernández-Carlos, B., Llaguno-Guilberto, J., Santos-Sánchez, N. F. (2017). Phenolic compounds in genus Smilax (Sarsaparilla). In M. Soto-Hernandez, M. Palma-Tenango, M. del Rosario Garcia-Mateos (Eds.), Phenolic compounds - natural sources. Importance and applications. InTech. Available from: http://www.intechopen.com/books/phenolic-com-pounds-natural-sources-importance-and-applications/phenolic-compounds-in-genus-smilax-sarsaparilla- Saltmarsh, M. (2013). Essential guide to food additives (4th ed). Cambridge, UK: RSC Publ. Sanchez-Vioque, R., Rodrigues-Conde, M. F., Reina-Urena,J. V., Escolano-Tercero, M. A., Herraiz-Penalver, D., Santana-Meridas, O. (2012). In vitro antioxidant and metal chelating properties of corm, petal and leaf from saffron (Crocus sativus L.). Ind. Crops Prod., 39, 149-153. https://doi.org/10.1016/j.indcrop.2012.02.028 Selim, K., Tsimidou, M., Biliaderis, C. G. (2000). Kinetic studies of degradation of saffron carotenoids encapsulated in amorphous polymer matrices. Food Chem., 71(2), 199-206. https://doi.org/10.1016/S0308-8146(00)00156-4 Seugn-Taik, L., Han, J. H. (2016). Improvement in anti- oxidant functionality and shelf life of yukwa (fried rice snack) by turmeric (Curcuma longa L.) powder addition. Food Chem., 199, 590-596. http://dx.doi.org/10.1016/j.foodchem.2015.12.046 Shahidi, F., Zhong,Y. (2010). Novel antioxidantsin food pres- ervation and health promotion. Eur. J. Lipid Sci. Tech- nol., 112(9), 930?940. http://doi.org/10.1002/ejlt.201000044 Shukla, Y., Singh, M. (2007). Cancer preventive properties of ginger: A brief review. Food Chem. Toxicol., 45(5), 683?690. https://doi.org/10.1016/j.fct.2006.11.002 Simon-Brown, K., Solval, K. M., Chotiko, A., Alfaro, L., Reyes, V., Liu, C., ..., Sathivel, S. (2016). Microencap- sulation of ginger (Zingiber officinale) extract by spray drying technology. LWT ? Food Sci. Technol., 70, 119-125. https://doi.org/10.1016/j.lwt.2016.02.030 Strimpakos, A. S., Sharma, R. A. (2008). Curcumin: preven- tive and therapeutic properties in laboratory studies and clinical trials. Antioxid. Redox Signal., 10(3), 511?545. https://doi.org/10.1089/ars.2007.1769 Tang, S. Z., Kerry, J. P., Sheehan, D., Buckley, D. J. (2001). A comparative study of tea catechins and ?-tocopherol as antioxidants in cooked beef and chicken meat. Eur. Food Res. Technol., 213(4), 286-289. https://doi.org/10.1007/ s002170100311 Topuz, A., Ozdemir, F. (2007). Assessment of carotenoids, capsaicinoids and ascorbic acid composition of some se- lected pepper cultivars (Capsicum annum L.) grown in Turkey. J. Food Comp. Anal., 20, 596-602. https://doi.org/10.1016/j.jfca.2007.03.007 Tremblay, F., Waterhouse, J., Nason, J., Kalt, W. (2013). Prophylactic neuroprotection by blueberry-enriched diet in a rat model of light-induced retinopathy. J. Nutr. Biochem., 24(4), 647?655. https://doi.org/10.1016/j.jnutbio.2012.03.011 Van Wyk B.-E., Wink, M. (2004). Medicinal plants of the world: An illustrated scientific guide to important me- dicinal plants and their uses. Portland, Ore, USA: Tim- ber Press. Vertuani, S., Angusti, A., Manfredini, S. (2004). The anti- oxidants and pro-antioxidants network: An overview. Curr. Pharmac. Design, 10(14), 1677?1694. https://doi.org/10.2174/1381612043384655 Wahyuni, Y., Ballester, A.-R., Sudarmonowati, E., Bino, R. J., Bovy, A. G. (2011). Metabolite biodiversity in pep- per (Capsicum) fruits of thirty-two diverse accessions: Variation in health-related compounds and implications for breeding. Pytochemistry, 72(11-12), 1358?1370. https://doi.org/10.1016/j.phytochem.2011.03.016 Wilken, R., Veena, M. S., Wang, M. B., Srivatsan, E. S. (2011). Curcumin: A review of anti-cancer properties and therapeutic activity inhead and neck squamous cell carcinoma. Mol. Cancer, 10(12), 1?19. http://dx.doi.org/10.1186/1476-4598-10-12 Winterhalter, P., Straubinger, M. (2000). Saffron ? Renewed interest in an ancient spice. Food Rev. Int., 16(1), 39?59. http://dx.doi.org/10.1081/FRI-100100281 Zafra-Stone, S., Yasmin, T., Bagchi, M., Chatterjee, A., Vinson, J. A., Bagchi, D. (2007). Berry anthocyanins as novel antioxidants in human health and disease preven- tion. Mol. Nutr. Food Res., 51(6), 675?683. http://doi.org/10.1002/mnfr.200700002 Zandi, P., Gordon, M. H. (1999). Antioxidant activity of ex- tracts from old tea leaves. Food Chem., 64(3), 285?288. https://doi.org/10.1016/S0308-8146(98)00047-8 Zimmer, A. R., Leonardi, B., Miron, D., Schapoval, E., Oli- veira, J. R., Gosmann, G. (2012). Antioxidant and anti- inflammatory properties of Capsicum baccatum: from traditional use to scientific approach. J. Ethnopharm., 139(1), 228-233. food preservation, natural antioxidants, phenolic extracts of fruits and spices, chemical structure of phenolic compounds 10.17306/J.AFS.0530

ORIGINAL_ARTICLE 371-377 en 2017 16 4 Urszula Złotek Ali, R. M., Abbas, H. M., Kamal, R. K. (2009). The effects of treatment with polyamines on dry matter and some metabolites in salinity ? stressed chamomile and sweet majoram seedlings. Plant Soil Environ., 55(11), 477?483. Angelova, Z., Georgiev, S., Roos, W. (2006). Elicitation of plants. Biotechn. Biotechnol. Equip., 20(2), 72?83. Baenas, N., García-Viguera, C., Moreno, D. A. (2014). Elicitation. A tool for enriching the bioactive composition of foods. Molecules, 19(9), 13541?13563. Brand-Williams, W., Cuvelier, M. E., Berset, C. (1995). Use of free radical method to evaluate antioxidant activity. Leben. Technol., 28, 25?30. Caldwell, C. R., Britz, S. J. (2006). Effect of supplemental ultraviolet radiation on the carotenoid and chlorophyll composition of greenhouse-grown leaf lettuce (Lactuca sativa L.) cultivars. J. Food Compos. Anal., 19(6), 637?644. Campos, F. M., Ribeiro, S. M. R., Della Lucia, C. M., Pinheiro-Sant?Ana, H. M., Stringheta, P. C. (2009). Optimization of methodology to analyze ascorbic and dehydroascorbic acid in vegetables. Quim. Nova, 32(1), 87?91. De Román, M., Fernández, I., Wyatt, T., Sahrawy, M., Heil, M., Pozo, M. J. (2011). Elicitation of foliar resistance mechanisms transiently impairs root association with arbuscular mycorrhizal fungi. J. Ecol., 99(1), 36?45. Gawlik-Dziki, U., Świeca, M., Dziki, D., Sugier, D. (2013). Improvement of nutraceutical value of broccoli sprouts by natural elicitors. Acta Sci. Pol. Hortorum Cultus., 12(1), 129?140. Hossain, M., Brunton, N., Patras, A., Tiwari, B. (2012). Optimization of ultrasound assisted extraction of antioxidant compounds from marjoram (Origanum majorana L.) using response surface methodology. Ultrason. Sonochem., 19(3), 582?590. Kim, H.-J., Chen, F., Wang, X., Rajapakse, N. C. (2006). Effect of methyl jasmonate on secondary metabolites of sweet basil (Ocimum basilicum L.). J. Agric. Food Chem., 54(6), 2327?2332. Kim, H.-J., Fonseca, J. M., Choi, J.-H., Kubota, C. (2007). Effect of methyl jasmonate on phenolic compounds and carotenoids of romaine lettuce (Lactuca sativa L.). J. Agric. Food Chem., 55(25), 10366?10372. Kocira, A., Świeca, M., Kocira, S., Złotek, U., Jakubczyk, A. (2016). Enhancement of yield, nutritional and nutraceutical properties of two common bean cultivars following the application of seaweed extract (Ecklonia maxima). Saudi J. Biol. Sci. https://doi.org/10.1016/j. sjbs.2016.01.039 Lin, K.-H., Huang, M.-Y., Huang, W.-D., Hsu, M.-H., Yang, Z.-W., Yang, C.-M. (2013). The effects of red, blue, and white light-emitting diodes on the growth, development, and edible quality of hydroponically grown lettuce (Lactuca sativa L. var. capitata). Sci Hortic., 150, 86?91. Malekpoor, F., Salimi, A., Pirbalouti, A. G. (2016). Effect of jasmonic acid on total phenolic content and antioxidant activity of extract from the green and purple landraces of sweet basil. Acta Pol. Pharm.Drug. Res., 73(5), 1229?34. Mulabagal, V., Ngouajio, M., Nair, A., Zhang, Y., Gottumukkala, A. L., Nair, M. G. (2010). In vitro evaluation of red and green lettuce (Lactuca sativa) for functional food properties. Food Chem., 118(2), 300?306. Nowak, K., Ogonowski, J. (2010). Marjoram oil, its characteristics and application. Chemik, 64(7?8), 539?548. Nurzyńska-Wierdak, R., Rożek, E., Bolanowska, K. (2012). Plon i jakość ziela melisy, majeranku oraz tymianku w zależności od sposobu uprawy w pojemnikach [The yield and quality of lemon balm, marjoram and thyme herb depending on the cultivation method]. Ann. Univ. Mariae Curie-Sklodowska Sect. EEE, 22(2), 1?11 [in Polish]. Oyaizu, M. (1986). Studies on products of browning reaction antioxidative activities of products of browning reaction prepared from glucosamine. Japan J. Nutr., 44, 307?315. Prerna, P., Vasudeva, N. (2015). Origanum majorana L. ? Phytopharmacological review. Indian J. Nat. Prod. Re sour., 6(4), 261?267. Reddy, M. K., Alexander-Lindo, R. L., Nair, M. G. (2005). Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. J. Agric. Food Chem., 53, 9268?9273. Saxena, D., Jayant, S. K., Soni, K., Neekhra, K. (2016). Origanum majorana, a potential herb for functional food. Eur. J. Pharm. Med. Res., 3(2), 321?325. Singleton, V. L., Rossi, J. A. (1965). Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am. J. Enol. Vitic., 16(3), 144?158. Świeca, M. (2016). Elicitation and treatment with precursors of phenolics synthesis improve low-molecular antioxidants and antioxidant capacity of buckwheat sprouts. Acta Sci. Pol. Technol. Alim., 15(1), 17?28. Vallverdú-Queralt, A., Regueiro, J., Alvarenga, J. F. R., Martinez-Huelamo, M., Leal, L. N., Lamuela-Raventos, R. M. (2015). Characterization of the phenolic and antioxidant profiles of selected culinary herbs and spices, caraway, turmeric, dill, marjoram and nutmeg. Food Sci. Technol., 35(1), 189?195. Zhao, J., Davis, L. C., Verpoorte, R. (2005). Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol. Adv., 23(4), 283?333. Złotek, U., Michalak-Majewska, M., Szymanowska, U. (2016). Effect of jasmonic acid elicitation on the yield, chemical composition, and antioxidant and antiinflammatory properties of essential oil of lettuce leaf basil (Ocimum basilicum L.). Food Chem., 213, 1?7. Złotek, U., Świeca, M., Jakubczyk, A. (2014). Effect of abiotic elicitation on main health-promoting compounds, antioxidant activity and commercial quality of butter lettuce (Lactuca sativa L.). Food Chem., 148, 253?260. Złotek, U., Świeca, M. (2016). Elicitation effect of Saccharomyces cerevisiae yeast extract on main health-promoting compounds and antioxidant and anti-inflammatory potential of butter lettuce (Lactuca sativa L.). J. Sci.Food Agric., 96(7), 2565?2572. Złotek, U., Szymanowska, U., Karaś, M., Świeca, M. (2016). Antioxidative and anti-inflammatory potential of phenolics from purple basil (Ocimum basilicum L.) leaves induced by jasmonic, arachidonic and ?-aminobutyric acid elicitation. Int. J. Food Sci. Technol., 51(1). antioxidant activity, elicitation, low-molecular weight antioxidants, marjoram 10.17306/J.AFS.0505

ORIGINAL_ARTICLE 379-391 en 2017 16 4 Rahel Getu Yetenayet B. Tola Satheesh Neela AACC (2000). Approved methods of the American Associa- tion of Cereal Chemists. Minnesota, USA: AACC. Adebayo, T. B. C., Adegoke, A. A., Akinjogunla, O. J. (2009). Microbial and physico-chemical quality of pow- dered soy milk samples in Akwa Ibom, South Southern Nigeria. Afr. J. Biotech., 8, 13, 3066?3071. Akhtar, S., Riaz, M., Ahmad, A., Nisar, A. (2010). Physico-chemical, microbiological and sensory stability of chem- ically preserved mango pulp. Pak. J. Bot., 42, 2, 853?862. AOAC (2010). Official methods of analysis of AOAC International. Washington DC, USA: AOAC. Augustine, C., Christian, I., Young, E. (2013). Nutrient con- tent, sensory characteristics and organoleptic acceptabil- ity of soy milk as functions of processing techniques. Annal. Food Sci. Tech., 14, 2, 241?246. Awonorin, S., Udeozor, L. (2014). Chemical properties of Tiger nut-Soy milk extract. IOSR J. Environ. Sci. Toxi- col. Food Techol., 8, 3, 87?98. Choonhahirun, A., Akesowan, A. (2012). Partial fat and sugar replacement with soy milk, inulin and sucralose on quality of Thai Pandanus custard. Afr. J. Biotech., 11, 20, 4611?4619. Coda, R., Lanera, A., Trani, A., Gobbetti, M., Di Cagno, R., (2012), Yogurt-like beverages made of a mixture of cereals, soy and grape must: Microbiology, texture, nutritional and sensory properties. Int. J. Food Micro- biol., 155, 1, 120?127. http://dx.doi.org/10.1016/j. ijfoodmicro.2012.01.016 Deshpande, R. P., Chinnan, M. S., McWatters, K. H. (2008). Optimization of a chocolate-flavored, peanut-soy bever- age using response surface methodology (RSM) as ap- plied to consumer acceptability data. LWT ? Food. Sci. Technol., 41(8), 1485?1492. http://dx.doi.org/10.1016/j. lwt.2007.08.013 Dewell, A., Hollenbeck, P. L. W., Hollenbeck, C. B. (2006). Clinical review: a critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations. J. Clin. Endo- crin. Metab., 91, 3, 772?780. http://dx.doi.org/10.1210/ jc.2004-2350 Doxastakis, G., Zafiriadis, I., Irakli, M., Marlani, H., Ta- nanaki, C. (2002). Lupin, soya and triticale addition to wheat flour doughs and their effect on rheological properties. Food Chem., 77, 2, 219?227. https://doi. org/10.1016/S0308-8146(01)00362-4 Drunkler, N. L., Leite, R. S., Mandarino, J. M. G., Ida, E. I., Demiate, I. M. (2012). Cassava starch as a stabilizer of soy-based beverages. Food Sci. Technol. Int., 18, 5, 489?499. http://dx.doi.org/10.1177/1082013211433072 Esteves, E. A., Martino, H. S. D., Oliveira, F. C. E., Bres- san, J., Costa, N. M. B. (2010). Chemical composition of a soybean cultivar lacking lipoxygenases (LOX2 and LOX3). Food Chem., 122, 1, 238?242. http://dx.doi. org/10.1016/j.foodchem.2010.02.069 Ezekiel, C. N., Fapohunda, S. O. (2012). Mycological and nutrient profile of soy milk. Global Adv. Res. J. Food Sci. Technol., 1, 2, 25?30. Fabiyi, E. F. (2006). Soybean processing. Utilization and health benefits. Pak. Nut., 5, 5, 453?457. Gatade, A., Ranveer, R., Sahoo, A. (2009). Physico-chem- ical and sensorial characteristics of chocolate prepared from soy milk. Adv. J. Food Sci. Tech., 1, 1, 1?5. Gesinde, A., Oyawoye, O., Adebisi, A. (2008). Comparitives studies on the quality and quantity of soy milk from dif- ferent varieties of soybean. Pak. J. Nut., 7, 1, 157?160. Hernández, O. M., Fraga, J. M. G., Jiménez, A. I., Jimé- nez, F., Arias, J. J. (2005). Characterization of honey from the Canary Islands: Determination of the mineral content by atomic absorption spectrophotometry. Food Chem., 93, 3, 449?458. http://dx.doi.org/10.1016/j. foodchem.2004.10.036 Hsieh, H. M., Wu, W. M., Hu, M. L. (2009). Soy isofla- vones attenuate oxidative stress and improve parameters related to aging and Alzheimer?s disease in C57BL/6J mice treated with D-galactose. Food Chem. Toxicol., 47, 3, 625?632. http://dx.doi.org/10.1016/j.fct.2008.12.026 Hunter Associates Laboratory (1996). CIE L* a* b* Color Scale, 8, 7, 1?4. Ikya, J., Gernah, D., Sengav, I. (2013). Proximate compo- sition, nutritive and sensory properties of fermented maize, and full fat soy flour blends for agidi produc- tion. Afr. J. Food Sci., 7, 12, 446?450. http://dx.doi. org/10.5897/AJFS09.224 Felberg, I., Deliza, R., Farah, A., Calado, E., Donangelo, C. M. (2010). Formulation of a soy-coffee beverage by response surface methodology and internal preference mapping. J. Sens. Stud., 25, 226?242. http://dx.doi. org/10.1111/J.1745-459x.2010.00278.X Jiang, S., Cai, W., Xu, B. (2013). Food quality improve- ment of soy milk made from short-time germinated soy- beans. Foods, 2, 2, 198?212. http://dx.doi.org/10.3390/ foods2020198 Kabiru, Y., Makun, H., Saidu, A., Muhammad, L., Nunth, L., Amoo, S. (2012). Soy milk preservation using extracts of cloves (Syzygium aromaticum Myrtaceae) and guinea-pepper (Xylopia aethiopica Annonaceae). IOSRJ. Pharm. Biol. Sci., 3, 5, 44?50. Kale, R., Pandhare, G., Satwase, A., Goswami, D. (2011). Effect of different concentration of orange juice on quality characteristics of soya milk blended bever- age. J. Food Proc. Technol., 3, 2, 2?6. http://dx.doi. org/10.4172/2157-7110.1000140 Kolapo, A. L., Oladimeji, G. R. (2008). Production and quality evaluation of soy-corn milk. J. Appl. Biosci., 1, 2, 40?45. Linda, M., Mackie, D., Butler, G., Larmond, E. (1991). Lab- oratory methods for sensory analysis of food. Ottawa, Canada: Canada Communication Group-Publishing Centre. Liu, F., Grauwet, T., Kebede, B. T., Van Loey, A., Liao, X., Hendrickx, M. (2014). Comparing the effects of high hydrostatic pressure and thermal processing on blanched and unblanched mango (Mangifera indica L.) nectar: us- ing headspace fingerprinting as an untargeted approach. Food Bioproc. Technol., 7, 10, 3000?3011. http://dx.doi. org/10.1007/s11947-014-1280-3 Madukwe, E., Eze Eme, P. (2012). Chemical evaluation and sensory attributes of soy milk fortified with carrot powder. Afr. J. Food Sci., 6, 20, 483?486. http://dx.doi. org/10.5897/AJFS12.040 Mojatahedi, P., Eivazzadeh, O., Mortazavian, A. M., Cham- ani, M. (2013). Laboratory production of tomato juice- based beverages ? soy milk. Adv. Environ. Biol., 7, 5, 823?829. Montgomery, D. C. (2013). Design and analysis of experi- ments. New York, USA: John Wiley and Sons. Naz, S., Anjum, M. A., Chohan, S., Akhtar, S., Siddique, B. (2014). Physico-chemical and sensory profiling of promising mango cultivars grown in peri-urban areas of Multan, Pakistan. Pak. J. Bot., 46, 1, 191?198. Okoye, J., Nkwocha, A., Ogbonnaya, A. (2008). Production, proximate composition and consumer acceptability of biscuits from wheat/soybean flour blends. Cont. J. Food Sci. Tech., 2, 1, 6?13. Olusola Omueti, Oguntona, E. B., Olayinka Jaiyeola, Ashaye, O. A. (2000). Nutritional evaluation of home- prepared soy-corn milk ? a protein beverage. Nut. Food Sci., 30, 3, 128?132. http://dx.doi.org/10.1108/00346650010319723 Omueti, O., Ajomale, K. (2005). Chemical and sensory at- tributes of soy-corn milk types. Afr. J. Biotech., 4, 8, 847?851. Ono, T., Choi, M. R., Ikeda, A., Odagiri, S. (1991). Chang- es in the composition and size distribution of soy milk protein particles by heating. Agric. Biol. Chem., 55, 9, 2291?2297. http://dx.doi.org/10.1080/00021369.1991.10870969 Onuorah, C. E., Adejare, A. O., Uhiara, N. S. (2007). Com- paritive physico-chemical evaluation of soy milk and soya cake produced by three different methods. Niger. Food J., 25, 2, 28?38. Onyeike, E. N., Olungwe, T., Uwakwe, A. A. (1995). Effect of heat-treatment and defatting on the proximate com- position of some Nigerian local soup thickeners. Food Chem., 53, 2, 173?175. https://doi.org/10.1016/0308-8146 (95)90784-5 Osborne, D. R., Voogt, P. I. (1978). The analysis of nutrients in foods. London, England: Academic Press. Pena, J., Gould, W., Hennessey, M., Hallman, G., Crane, J. (2006). Laboratory and field infestation studies on imma- ture green ?Tommy Atkins? and ?Keitt? mangoes to de- termine host status to the caribbean fruit fly (Diptera: Te- phritidae). Proc. Florida State Hortic. Soc., 119, 16?20. Peter, M., Leonard, F., Bernard, C., Joyce, K., Victor, G., Kaswija, M. (2007). Physical and chemical character- istics of off vine ripened mango (Mangifera indica L .) fruit (Dodo). J. Biotech., 6, 21, 2477?2483. Potter, R. M., Dougherty, M. P., Halteman, W. A., Camire,M. E. (2007). Characteristics of wild blueberry-soy beverages. LWT ? Food Sci. Technol., 40, 2, 807?814. http://dx.doi.org/10.1016/j.lwt.2006.04.006 Prinyawiwatkul, W., Mcwatters, K. H., Beuchat, L. R., Phil- lips, R. D. (1997). Optimizing acceptability of chicken nuggets containing fermented cowpea and peanut flours. J. Food Sci., 62, 4, 889?894. Ribeiro, G. P., de Andrade, A. P. C., Daniels, J., Seibel, N.F. (2014). Development of soy-based beverages with papaya and mango pulp. Acta Scientiarum ? Technol., 36, 2, 341?347. http://dx.doi.org/10.4025/actascitechnol. v36i2.21958 Rozina, N. (2012). Development and evaluation of fruit fla- vored soy milk. Pak. J. Food Sci., 22, 3, 154?160. Sadler, G., Davis, J., Dezman, D. (1990). Rapid extraction of lycopene and beta carotene from reconstituted tomato paste and pink grapefruit homogenates. J. Food Sci., 55, 5, 1460?1461. Sakhale, B. K., Pawar, V. N., Ranveer, R. C. (2012). Studies on development of soy milk based mango RTS beverage. Elect. J. Environ. Agric. Food Chem., 11, 5, 523?528. Salim, R., Haq, S., Muhammad, M., Sarfraz, H. (2007). Physico-chemical and sensroy evaluation of ready to drink soy-cow milk blend. Pak. J. Nutr., 6, 3, 283?282. Singh, Z., Singh, R. K., Sane, V. A., Nath, P., (2013). Man- go ? postharvest biology and biotechnology. Crit. Rev. Plant Sci., 32, 4, 217?236. http://dx.doi.org/10.1080/07352689.2012.743399 Sowonola, O. A., Tunde-Akintunde, T. Y., Adedeji, F. (2005). Nutritional and sensory qualities af soy milk kunnu blends. Afr. J. Food Nutr. Sci., 5, 2, 140?147. Touba, I., Zahra, I., Mostafa, M. T., Mandana, A. P., Mo- hammad, Z. M., Mohammad, A. S. (2013). Investigation of optimized methods for improvement of organolepti- cal and physical properties of soy milk. Int. J. Farm Al- lied Sci., 2, 10, 245?250. Trindade, C. S., Terzi, S. C., Trugo, L. C., Della Modesta, R. C., Couri, S. (2001). Development and sensory evalua- tion of soy milk based yoghurt. Arch. Latinoamer. Nutr., 51(1), 100?104. Udeozor, L. O., Awonorin, S. O. (2014). Comparative mi- crobial analysis and storage of tigernut-soy milk extract. Austin J. Nutr. Food Sci., 2(5), 1?6. USDA (2017). World agriculture production for March 2017. Retrieved from http://apps.fas.usda.gov/psdon- line/circulars/production.pdf. Vaintraub, I. A., Lapteva, N. A. (1988). Colorimetric deter- mination of phytate in unpurified extracts of seeds and the products of their processing. Anal. Biochem., 175, 1, 227?230. White, J. S. (2014). Sucrose, HFCS, and fructose: history, manufacture, composition, applications, and production. In J. M. Rippe (Ed.), Fructose, high fructose corn syrup, sucrose and health (pp. 13?33). Springer. Zulueta, A., Esteve, M. J., Frasquet, I., Frígola, A. (2007). Vitamin C, vitamin A, phenolic compounds and to- tal antioxidant capacity of new fruit juice and skim milk mixture beverages marketed in Spain. Food Chem., 103, 4, 1365?1374. http://dx.doi.org/10.1016/j. foodchem.2006.10.052 beany flavor, blended beverage, mango nectar, sensory properties, soy milk 10.17306/J.AFS.0506

ORIGINAL_ARTICLE 393-401 en 2017 16 4 Barbara Pliszka Charlebois, D., Byers, P. L., Finn, Ch. E., Thomas, A. L. (2010) Elderberry: Botany, Horticulture, Potential. Hortic. Rev., 37, 213?280. Christensen, L. P., Kaack, K., Frette, X. C. (2008) Selection of elderberry (Sambucus nigra L.) genotypes best suited for the preparation of elderflower extracts rich in flavonoids and phenolic acids. Eur. Food Res. Technol., 227, 293?305. http://dx.doi.org/10.1007/s00217-007-0723-8 Dawidowicz, A. L., Wianowska, D., Baraniak, B. (2006) The antioxidant properties of alcoholic extracts from Sambucus nigra L. (antioxidative properties of extracts). Food Sci. Technol., 39(3), 308?315. http://dx.doi. org/10.1016/j.lwt.2005.01.005 Drdak, M., Daucik, P. (1990) Changes of elderberry (Sambucus nigra) pigments during the production of pigment concentrates. Acta Aliment., 19, 3?7. Fassatiova, O. (1883). Grzyby mikroskopowe w mikrobiologii technicznej [Microscopic mushrooms in technical microbiology]. Warszawa, Poland: WNT [in Polish]. Fuleki, T., Francis, F. J. (1968). Quantitative methods for anthocyanins. 2. Determination of total anthocyanin and degradation index for cranberry juice. J. Food Sci., 33, 78?83. http://dx.doi.org/10.1111/j.1365-2621.1968. tb00888.x Jakobek, L., Šeruga, M., Novak, I., Medvidović-Kosanović, M. (2007). Flavonols, phenolic acids and antioxidant activity of some red fruits. Deutsche Lebensmittel-Rundschau, 103. Jahrgang, 8, 369?378. Jay, J. M., Loessner, M. J., Golden, D. A. (2005). Modern food microbiology. New York: Springer Science + Business Media. Kaack, K., Austed, T. (1998). Interaction of vitamin C and flavonoids in elderberry (Sambucus nigra L.) during juice processing. Plant Foods Hum. Nutr., 52(3), 187?198. Kaack, K., Frette, X. C., Christensen, L. P., Landbo, A. K., Meyer, A. S. (2008). Selection of elderberry (Sambucus nigra L.) genotypes best suited for the preparation of juice. Eur. Food Res. Technol., 226, 843?855. http:// dx.doi.org/10.1007/s00217-007-0605-0 Karou, D., Dicko, M. H., Simpore, J., Traore, A. S. (2005). Antioxidant and antibacterial activities of polyphenols from ethnomedicinal plants of Burkina Faso. Afr. J. Biotechnol., 4(8), 823?828. Krieg, N. R., Holt, J. G. (1994). Bergey?s manual of determinative bacteriology. Baltimore: Williams & Wilkins. Lee, J., Finn, C. E. (2007). Anthocyanins and other polyphenolics in American elderberry (Sambucus Canadensis) and European elderberry (S. nigra) cultivars. J. Sci. Food Agric., 87, 2665?2675. http://dx.doi.org/10.1002/ jsfa.3029 Miller, N. J., Rice-Evans, C., Davies, M. J., Gopinathan, V., Milner, A. (1993). A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin. Sci., 84, 407?412. http://dx.doi.org/10.1042/cs0840407 Netzel, M., Strass, G., Herbst, M., Dietrich, H., Bitsch, I., Frank, T. (2005). The excretion and biological antioxidant activity of elderberry antioxidants in healthy humans. Food Res. Int., 38, 905?910. http://dx.doi. org/10.1016/j.foodres.2005.03.010 Pliszka, B., Huszcza-Ciołkowska, G., Mieleszko, E., Czaplicki, S. (2009). Stability and antioxidative properties of acylated anthocyanins in three cultivars of red cabbage (Brassica oleracea L. var. capitata L. f. rubra). J. Sci. Food Agric., 89, 1154?1158. http://dx.doi. org/10.1002/jsfa.3565 Pliszka, B., Huszcza-Ciołkowska, G., Januszewicz, E., Warmińska-Radyko, I. (2013). Stability, microbiological quality and antioxidant properties of extract from berry fruits. Acta. Aliment., 42(2), 256?263. http://dx.doi.org/ 10.1556/AAlim.42.2013.2.13 Pliszka, B., Huszcza-Ciołkowska, G., Wierzbicka, E. (2016). Effects of solvents and extraction methods on the content and antiradical activity of polyphenols from fruits Actinidia Arguta, Crataegus Monogyna, Gaultheria Procumbens and Schisandra Chinensis. Acta Sci. Pol. Technol. Aliment., 15(1), 57?63. http://dx.doi.org/10.17306/ J.AFS.2016.1.6 Pizło, A., Jankowska, D. (2001). Trwałość barwnika dzikiego bzu czarnego w wódkach [Stability of wild elderberry pigment in vodkas]. Przem. Ferm. Owoc.-Warzyw., 45(1), 16?18 [in Polish]. Puupponen-Pimiä, R., Nohynek, L.,Alakomi, H. L., Oksman-Caldentey, K. M. (2005). Bioactive berry compounds ? novel tools against human pathogens. Appl. Microbiol. Biotechnol., 67(1), 8?18. http://dx.doi.org/10.1007/ s00253-004-1817-x Raybaudi-Massilia, R. M., Mosqueda-Melgar, J., Soliva-Fortuny, R., Martin-Belloso, O. (2009). Control of pathogenic and spoilage microorganisms in freshcut fruits and fruit juices by traditional and alternative natural antimicrobials. CRFSFS: Compr. Rev. Food Sci. Food Safety, 8, 157?180. http://dx.doi.org/10.1111/j.1541-4337.2009.00076.x Salvador, Â. C., Król, E., Lemos, V. C., Santos, S.A. O., Bento, F. P. M. S., Costa, C. P., ..., Rocha, S. S. M. (2017). Effect of elderberry (Sambucus nigra L.) extract supplementation in STZ-induced diabetic rats fed with a high-fat diet. Int. J. Mol. Sci., 18, 1?19. http://dx.doi.org/10.3390/ijms18010013 Rose, A. H., Harrison, J. S. (1970). The yeasts. New York: Acad. Press London. Sapers, G. M., Taffer, I., Ross, L. R. (1981). Functional properties of a food colorant prepared from red cabbage. J. Food Sci., 46, 105?109. http://dx.doi.org/10.1111/j.1365-2621. 1981.tb14540.x Vatai, T., Skerget, M., Knez, Z. (2009). Extraction of phenolic compounds from elderberry and different grape marc varieties using organic solvents and/or supercritical carbon dioxide. J. Food Eng., 90, 246?254. http://dx.doi. org/10.1016/j.jfoodeng.2008.06.028 Veberic, R., Jakopic, J., Stampar, F., Schmitzer, V. (2009). European elderberry (Sambucus nigra L.) rich in sugar, organic acids, anthocyanins and selected polyphenols. Food Chem., 114, 511?515. http://dx.doi.org/10.1016/j. foodchem.2008.09.080 Waźbińska, J., Puczel, U. (2002). Fruit Characteristics of the elderberry (Sambucus nigra L.) grown on two different soils. J. Fruit Ornam. Plant Res., 10, 111?121. Wu, X., Cao, G., Prior, R. L. (2002). Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry. J. Nutr., 132(7), 1865?1871. Yen, G. C., Hung, C. Y. (2000). Effects of alkaline and heat treatment on antioxidative activity and total phenolics of extracts from Hsiantsao (Mesona procumbens Hemsl.). Food Res. Int., 33, 487?492. http://dx.doi.org/10.1016/ S0963-9969(00)00073-9 Zakay-Rones, Z., Varsano, N., Zlotnik, M., Manor, O., Regev, L., Schlesinger, M., Mumcuoglu, M. (1995). Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J. Altern. Compl. Med., 1(4), 361?369. http://dx.doi. org/10.1089/acm.1995.1.361 ABTS, DPPH, elderberries, HPLC, microbiologia, stability 10.17306/J.AFS.0523

ORIGINAL_ARTICLE 403-412 en 2017 16 4 He Chen Jie Huang Xiaoyu Shi Yichao Li Yu Liu Abadias, M., Benabarre, A., Teixido, N., Usall, J., Vi, I. (2001). Effect of freeze drying and protectants on viability of the biocontrol yeast Candida sake. Int. J. Food Microbiol., 65(3), 173?182. Allison, S. D., Chtang, B., Randolph, T. W., Carpenter, J. F. (1999). Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding. Arch. Biochem. Biophys. Arch., 365(8), 289?298. Carvalho, A., Silva, J., Ho, P., Teixeira, P., Malcata, F. X., Gibbs, P. (2003). Protective effect of sorbitol and mono-sodium glutamate during storage of freeze-dried lactic acid bacteria. Lait, 83, 203?210. Chitra, T., Lian, Y., Suryanarayanan, R. (2003). Effective inhibition of mannitol crystallization in frozen solutions by sodium chloride. Pharm. Res., 20(4), 660?667. Dhewa, T., Pant, S., Mishra, V. (2014). Development of freeze dried synbiotic formulation using a probiotic strain of Lactobacillus plantarum. J. Food Sci. Technol., 51(1), 83?89. De Paz, R. A., Dale, D. A., Barnett, C. C., Carpenter, J. F., Gaertner, A. L., Randolph, T. W. (2002). Effects of drying methods and additives on the structure, function, and storage stability of subtilisin: role of protein conformation and molecular mobility. Enzyme Microb. Technol., 31(6), 765?774. Guchte, M. V. D., Penaud, S., Grimaldi, C., Barbe, V., Brys- on, K., Nicolas, P., ?, Maguin, E. (2006). The complete genome sequence of Lb. delbrueckii subsp. bulgaricus reveals extensive and ongoing reductive evolution. Proc. Nat. Acad. Sci., 103(24), 9274?9279. Guillouard, I., Lim, E. M., Guchte, M. V. D., Grimaldi, C., Penaud, S., Maguin, E. (2004). Tolerance and adaptative acid stress of Lactobacillus delbrueckii subsp. bulgaricus. Lait, 84(1?2), 1?6. Herrera, M., Segura, A., Sanchez, A., Sanchez, A., Vargas, M., Villalta, M., ?, Leon, G. (2017). Freeze-dried EchiTAb+ICP antivenom formulated with sucrose is more resistant to thermal stress than the liquid formulation stabilized with sorbitol. Toxicon., 133, 123?126. Hofvendahl, K., Hahn-Hagerdal, B. (2000). Factors affecting the fermentative lactic acid production from renewable resources. Enzyme Microb. Technol., 26(2?4), 87?107. Hutkins, R. W., Ellefson, W. L., Kashket, E. R. (1987). Betaine transport imparts osmotolerance on a strain of Lactobacillus acidophilus. Appl. Environ. Microbiol., 53, 2275?2281. Kets, E. P. W., de Bont, J. A. M. (1994). Protective effect of betaine on survival of Lactobacillus plantarum subjected to drying. FEMS Microbiol. Lett., 116(3), 251?256. Kets, E. P. W., Teunissen, P. J. M., Bont, J. A. M. (1996). Effect of compatible solutes on survival of lactic acid bacteria subjected to drying. Appl. Environ. Microbiol., 62(1), 259?261. Li, C., Sun, J. W., Qi, X. X., Liu, L. B. (2015). NaCl stress impact on the key enzymes in glycolysis from Lb. delbrueckii subsp. bulgaricus during freeze-drying. Braz. J. Microbiol., 46(4), 1193?1199. Lim, C. M., Rahim, R. A., Ho, Y. W., Ariff, A. B. (2009). Formulation of protective agents for improvement of Lactobacillus salivarius I 24 survival rate subjected to freeze drying for production of live cells in powderized form. Food Bioproc. Technol., 2(4), 431?436. Louesdon, S., Charlot-Rouge, S., Juillard, V., Tourdot-Marechal, R., Beal, C. (2014). Osmotic stress affects the stability of freeze-dried Lactobacillus buchneri R1102 as a result of intracellular betaine accumulation and membrane characteristics. J. Appl. Microbiol., 117(1), 196?207. http://dx.doi.org/10.1111/jam.12501 Morgan, C., Vesey, G. (2009). Freeze-drying of microorganisms. In Encyclopedia of Microbiology (pp. 162?173). Academic Press. http://dx.doi.org/10.1016/B978-0123 73944-5.00114-0 Shahgaldian, P., Gualbert, J., A?ssa, K., Coleman, A. W. (2003). A study of the freeze-drying conditions of calixarene based solid lipid nanoparticles. Eur. J. Pharm. Biopharm., 55, 181?184. Santivarangkna, C., Higl, B., Foerst, P. (2008). Protection mechanism of sugars during different Stages of preparation process of dried lactic acid starter cultures. Food Microbiol., 25(3), 429?441. Srinivasan, J. M., Wegiel, L. A., Hardwick, L. M., Nail, S. L. (2017). the influence of mannitol hemihydrate on the secondary drying dynamics of a protein formulation: A case study. J. Pharm. Sci. http://dx.doi.org/10.1016/j. xphs.2017.08.018 Thammavongs, B., Corroler, D., Panoff, J. M., Auffray, Y., Boutibonnes, P. (1996). Physiological response of Enterococcus faecalis JH2-2 to cold shock: growth at low temperatures and freezing/thawing challenge. Lett. Appl. Microbiol., 23(6), 398?402. Valdez, G. F., Giori, G. S., Ruiz Hoigado, A. A. P., Oliver, G. (1985). Effect of drying medium on residual moisture content and viability of freeze-dried lactic acid bacteria. Appl. Environ. Microbiol., 49, 413?415. Lactobacillus delbrueckii subsp bulgaricus, antifreeze factors, freeze-drying, single-factor test, PB screening test 10.17306/J.AFS.0512

ORIGINAL_ARTICLE 413-420 en 2017 16 4 Joanna Żochowska-Kujawska Marek Kotowicz Kazimierz Lachowicz Małgorzata Sobczak Albright, S. N., Kendall, P. A., Sofos, J. N. (2000). Sensory properties of beef jerky processed under various condi- tions. In Proceedings of IFT annual meeting. June 10? 14, 2000. Session 11. Dallas, TX, USA. Ashie, I. N. A., Sorensen, T. L., Nielsen, P. M. (2002). Ef- fect of papain and a microbial enzyme on meat proteins and beef tenderness. J. Food Sci., 67, 2138?2142. http:// dx.doi.org/10.1111/j.1365-2621.2002.tb09516.x Berge, P., Ertbjerg, P., Larsen, L. M., Astruc, T., Vignon, X., Moller, A. J. (2001). Tenderization of beef by lactic acid injected at different times post mortem. Meat Sci., 57, 347?357. Bourne, M. C. (1982), Food texture and viscosity. New York: Academic Press. Burck, H. Ch. (1975). Utrwalanie [Fixation]. In Tech- nika histologiczna (pp. 62?63). PZWL: Warszawa [in Polish]. Burke, R. M., Monahan, F. J. (2003). The tenderization of shin beef using a citrus juice marinade. Meat Sci., 63, 161? 168. http://dx.doi.org/10.1016/S0309-1740(02)00062-1 Gault, N. F. S. (1991). Marinated meat. In R. Lawrie (Ed.), Developments in meat science (vol. 5, pp. 191?245). London: Elsevier Science. Ionescu, A., Aprodu, I., Pascaru, G. (2008). Effect of papain and bromelin on muscle and collagen proteins in beef meat. Annal. Univ. Dunarea Galati Fascicle VI, Food Techn., 31, 9?16. Ketnawa, S., Rawdkuen, S., Chaiwut, P. (2010). Two phase partitioning and collagen hydrolysis of bromelain from pineapple peel Nang Lae cultivar. Biochem. Eng., J., 52, 205?211. http://dx.doi.org/10.1016/j.bej.2010.08.012 Konieczny, P., Kowalski, R., Pyrcz, J. (2004). Selected quality attributes of dried snack foods made from beef. Żywn. Nauka Techn. Jakość, 3(40), 32?39. Konieczny, P., Stangierski, J., Kijowski, J. (2007). Physical and chemical characteristics and acceptability of home style beef jerky. Meat Sci., 76, 253?257. http://dx.doi. org/10.1016/j.meatsci.2006.11.006 Lee, Y. B., Sehnert, D. J., Ashmore, C. R. (1986). Tenderiza- tion of meat with ginger rhizome protease. J. Food Sci., 51, 1558?1559. http://dx.doi.org/10.1111/j.1365-2621.1986.tb13860.x Lewis, G. J., Purslow, P. P. (1991). The effect of marination and cooking on the mechanical properties of intramus- cular connective tissue. J. Muscle Foods, 2, 177?195. http://dx.doi.org/10.1111/j.1745-4573.1991.tb00452.x Naveena, B. M., Mendiratta, S. K. (2001). Tenderization of spent hen meat using ginger extract. Br. Poultry Sci., 42, 3, 344?350. http://dx.doi.org/10.1080/00071660120055313 Oreskovich, D. C., Bechtel, P. J., McKeith, F. K., Novakof- ski, J., Basgall, E. J. (1992). Marinade pH affects tex- tural properties of beef. J. Food Sci., 57, 305?311. http:// dx.doi.org/10.1111/j.1365-2621.1992.tb05482.x Paleari, M. A., Beretta, G., Colombo, F., Foschini, S., Ber- tolo, G., Camisasca, S. (2000). Buffalo meat as a salted and cured product. Meat Sci., 54, 365?367. http://dx.doi. org/10.1016/S0309-1740(99)00111-4 Sales, J., Kotrba, R. (2013). Meat from wild boar (Sus scro- fa L.): A review. Meat Sci., 94, 187?201. http://dx.doi. org/10.1016/j.meatsci.2013.01.012 Scheinberg, J. A., Svoboda, A. L., Cutter, C. N. (2014). High-pressure processing and boiling water treatments for reducing Listeria monocytogenes, Escherichia coli O157:H7, Salmonella spp., and Staphylococcus aureus during beef jerky processing. Food Contr., 39, 105?110. http://dx.doi.org/10.1016/j.foodcont.2013.11.002 Sloan, A. (2011). Top 10 food trends. J. Food Technol., 65(49), 24?40. Soriano, A., Cruz, B., Gómez, L., Mariscal, C., García-Ruiz, A. (2006). Proteolysis, physicochemical characteristics and free fatty acid composition of dry sausages made with deer (Cervus elaphus) or wild boar (Sus scrofa) meat: A preliminary study. Food Chem., 96, 173?184. http://dx.doi.org/10.1016/j.foodchem.2005.02.019 Wada, M., Suzuki, T., Yaguti, Y., Hasegawa, T. (2002). The effect of pressure treatments with kiwi fruit protease on adult cattle semitendinosus muscle. Food Chem., 78(2), 167?171. http://dx.doi.org/10.1016/S0308-8146(01)00395-8 Żochowska-Kujawska, J., Lachowicz, K., Sobczak, M. (2012). Effects of fibre type and kefir, wine lemon, and pineapple marinades on texture and sensory prop- erties of wild boar and deer longissimus muscle. Meat Sci., 92, 675?680. http://dx.doi.org/10.1016/j.meatsci.2012.06.020 Żochowska-Kujawska, J., Sobczak, M., Lachowicz, K. (2009). Comparison of the texture, rheological proper- ties and myofibre characteristics of SM (semimembra- nosus) muscle of selected species of game animals. Pol. J. Food Nutr. Sci., 59(3), 243?246. jerky, roe deer, wild boar, structure, Warner-Bratzler parameters 10.17306/J.AFS.0508

ORIGINAL_ARTICLE 421-429 en 2017 16 4 Marek Sady Dorota Najgebauer-Lejko Jacek Domagała Champagne, C. P., Ross, R. P., Saarela, M., Hansen, K. F., Charalampopoulos, D. (2011). Recommendations for the viability assessment of probiotics as concentrated cultures and in food matrices. Int. J. Food Microbiol., 149, 3, 185?193. http://dx.doi.org/10.1016/j.ijfoodmicro.2011.07.005 Granato, D., Branco, G. F., Nazzaro, F., Cruz, A. G., Faria, J. A. F. (2010). Functional foods and nondairy probiotic food development: Trends, concepts, and products. Compr. Rev. Food Sci., F., 9, 292?302. http://dx.doi.org/10.1111/j.1541-4337.2010.00110.x Jarczyk, A., Płocharski, W. (2010). Technologia produktów owocowych i warzywnych [Technology of fruit and vegetable products]. Skierniewice: Wyd. Wyższej Szkoły Ekonomiczno-Humanistycznej [in Polish]. Jaworska, G., Grega, T., Sady, M., Bernaś, E. Pogoń, K. (2014). Quality of apple-whey and apple beverages over 12-month storage period. J. Food Nutr. Res., 53, 2, 117?126. Jaworska, G., Sady, M., Grega, T., Bernaś, E., Pogoń, K. (2011). Qualitative comparison of blackcurrant and blackcurrant-whey beverages. Food Sci. Technol. Int., 17(4), 331?342. http://dx.doi.org/10.1177/1082013210382480 Jelen, P. (2003). Whey processing: Utilization and products. In H. Roginski, J. F. Fuquay, P. F. Fox (Eds.), Encyclopedia of dairy sciences (pp. 2739?2745). London: Academic Press. Jeličić, I., Božanić, R., Tratnik, L. (2008). Whey-based beverages ? a new generation of dairy products. Mljekarstvo, 58(3), 257?274. Khezri, S., Dehghan, P., Mahmoudi, R., Jafarlou, M. (2016). Fig juice fermented with lactic acid bacteria as a nutraceutical product. Pharm. Sci., 22, 260?266. http://dx.doi.org/10.15171/PS.2016.40 Mahmoudi, R., Tajik, H., Ehsani, A., Farshid, A. A., Zare, P., Hadian, M. (2013). Effects of Mentha longifolia L. essential oil on viability and cellular ultrastructure of Lactobacillus casei during ripening of probiotic Feta cheese. Int. J. Dairy Technol., 66, 77?82. http://dx.doi.org/10.1111/j.1471-0307.2012.00867.x Mandal, S., Hati, S. (2016). Diversification of probiotics through encapsulation technology. Intl. J. Food. Ferment., 5(1), 53?61. http://dx.doi.org/10.5958/2321-712X.2016.00007.7 Marhamatizadeh, M. H., Rezazadeh, S., Kazemeini, F., Kazemi, M. R. (2012). The study of probiotic juice product conditions supplemented by culture of Lactobacillus acidophilus and Bifidobacterium bifidum. Middle-East J. Sci. Res., 11(3), 287?295. PN-EN 1132:1999. Soki owocowe i warzywne ? Oznaczanie pH [Polish Standard PN-EN 1132:1999. Fruit and vegetable juices ? Determination of pH; in Polish]. PN-EN 12147:2000. Soki owocowe i warzywne ? Oznaczanie kwasowości miareczkowej [Polish Standard PN-EN 12147:2000. Fruit and vegetable juices ? Determination of titrable acidity; in Polish]. PN-EN ISO 7218:2008. Mikrobiologia żywności i pasz ? Wymagania ogólne i zasady badań mikrobiologicznych [Polish Standard PN-EN ISO 7218:2008. Microbiology of food and animal feeding stuffs ? General requirements and guidance for microbiological examinations; in Polish]. PN-EN ISO 6887-1:2000. Mikrobiologia łańcucha żywnościowego ? Przygotowanie próbek do badań, zawiesiny wyjściowej i rozcieńczeń dziesięciokrotnych do badań mikrobiologicznych ? Część 1: Ogólne zasady przygotowania zawiesiny wyjściowej i rozcieńczeń dziesięciokrotnych [Polish Standard PN-EN ISO 6887-1:2000. Microbiology of food and animal feeding stuffs ? Preparation of test samples, initial suspension and decimal dilutions for microbiological examination; in Polish]. Rivera-Espinoza, Y., Gallardo-Navarro, Y. (2010). Non-dairy probiotic products. Food Microbiol., 27, 1?11. Saarela, M. (2009). Probiotics as ingredients in functional beverages. In P. Paquin (Eds.), Functional and speciality beverage technology (pp. 55?70). Boca Raton, FL, USA: Woodhead Publ., CRC Press. Saarela, M., Virkajärvi, I., Alakomi, H. L., Sigvart-Mattila, P., Mättö, J. (2006). Stability and functionality of freeze-dried probiotic Bifidobacterium cells during storage in juice and milk. Int. Dairy J., 16, 1477?1482. http:// dx.doi.org/10.1016/j.idairyj.2005.12.007 Sadaghdar, Y., Mortazavian, A. M., Ehsani, M. R. (2012). Survival and activity of 5 probiotic lactobacilli strains in 2 types of flavored fermented milk. Food Sci. Biotechnol., 21(1), 151?157. http://dx.doi.org/10.1007/s10068-012-0019-z Sady, M., Jaworska, G., Grega, T., Bernaś, E., Domagała, J. (2013). Application of acid whey in orange drink production. Food Technol. Biotechnol., 51(2), 266?277. Sasi Kumar, R. (2015). Development, quality evaluation and shelf life studies of probiotic beverages using whey and Aloe vera juice. J. Food Process Technol., 6, 486. http://dx.doi.org/10.4172/2157-7110.1000486 Shah, C., Mokashe, N., Mishra, V. (2016). Preparation, characterization and in vitro antioxidative potential of synbiotic fermented dairy products. J. Food Sci. Technol., 53(4), 1984?1992. http://dx.doi.org/10.1007/s13197-016-2190-3 Sheehan, V. M., Ross, P., Fitzgerald, G. F. (2007). Assessing the acid tolerance and the technological robustness of probiotic cultures for fortification in fruit juices. Innov. Food Sci. Emerg. Technol., 8, 279?284. http://dx.doi.org/10.1016/j.ifset.2007.01.007 Shori, A. B. (2016). Influence of food matrix on the viability of probiotic bacteria: A review based on dairy and non-dairy beverages. Food Bioscience, 13, 1?8. http://dx.doi.org/10.1016/j.fbio.2015.11.001 Shukla, M., Jha, Y. K., Admassu, S. (2013). Development of probiotic beverage from whey and pineapple juice. J. Food Process Technol., 4, 206. http://dx.doi.org/10.4172/2157-7110.1000206 Tharmaraj, N., Shah, N. P. (2003). Selective enumeration of Lactobacillus delbrueckii ssp. bulgaricus, Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacteria, Lactobacillus casei, Lactobacillus rhamnosus, and Propionibacteria. J. Dairy Sci., 86, 2288?2296. Wildman, E. C., Kelley, M. (2007). Nutraceuticals and Functional Foods. In E. C. Wildman (Eds.), Handbook of nutraceuticals and functional foods (pp. 1?20). Boca Raton, FL: CRC Press. whey, fruit drink, probiotics, viability, acidity 10.17306/J.AFS.0515

ORIGINAL_ARTICLE 431-442 en 2017 16 4 Chima A. Ekeleme-Egedigwe Ifeoma I. Ijeh Polycarp N. Okafor Abbott, R. D., Wilson, P. W., Kannel, W. B., Castelli, W.P. (1988). High density lipoprotein-cholesterol, total cholesterol screening and myocardial infarction. The Framingham Study. Arterioscl. Thromb. Vasc. Biol., 8, 207?211. https://doi.org/10.1161/01.ATV.8.3.207 Abdollahi, M., Afshar-Imani, B. (2003). A review on obesity and weight loss measures. Middle East Pharm., 11, 6?10. Adaramoye, O. A., Akintayo, O., Achem, J., Fafunso, M.A. (2008). Lipid-lowering effects of methanolic extract of Vernonia amygdalina leaves in rats fed on high cholesterol diet. Vasc. Health Risk Manag., 4(1), 235?241. PMCID: PMC2464769. Adeneye, A. A., Adeyemi, O. O., Agbaje, E. O. (2010). Anti-obesity and antihyperlipidaemic effect of Hunteria umbellata seed extract in experimental hyperlipidaemia. J. Ethnopharm., 130, 307?314. http://dx.doi.org/10.1016/j.jep.2010.05.009 Agbogidi, O. M., Akpomorine, M. O. (2013). Health and nutritional benefits of bitter leaf (Vernonia amygdalina Del.). Int. J. Appl. Pharm. Sci. BioMed. Sci., 2(3), 164?170. Akah, P. A., Okafor, C. I. (1992a). Blood sugar lowering effect of Vernonia amygdalina (Del) in an experimental rabbit model. Phytother. Res., 6(3), 171?173. http://dx.doi.org/10.1002/ptr.2650060318 Akah, P. A., Okafor, C. I. (1992b). Hypoglycaemic effect of Vernonia amygdalina (Del) in experimental rabbits. J. Med. Plants Res., 1, 6?10. Allain, C. C., Poon, L. S., Chan, C. S., Richmond, W., Fu, P.C. (1974). Enzymatic colorimetric method for cholesterol estimation. Clin. Chim., 20, 470?475. PMID:4818200. Atangwho, I. J., Ebong, P. E., Eyong, E. U., Eteng, M. U., Uboh, F. E. (2007a). Vernonia amygdalina Del: A potential prophylactic antiiabetic agent in lipid complication. Global J. Pure Appl. Sci., 18(1), 103?106. Atangwho, I. J., Ebong, P. E, Egbung, G. E., Eteng, M. U., Eyong, E. U. (2007b). Effect of Vernonia amygdalina Del. on liver function in alloxan-induced hyper glycemic rats. J. Pharm. Bioresour., 4, 25?31. http://dx.doi.org/10.4314/jpb.v4i1.32107 Atangwho, I. J., Edet, E. E., Uti, D. E., Obi, A. U., Asmawi,M. Z., Ahmad, M. (2012). Biochemical and histological impact of Vernonia amygdalina supplemented diet in obese rats. Saudi J. Biol. Sci., 19, 385?392. Balaji, M., Ganjayi, M. S., Hanuma Kumar, G. E. N., Parim, B. N., Mopuri, R., Dasari, S. (2015). A review on possible therapeutic targets to contain obesity: The role of phytochemicals. Obesity Res. Clin. Pract., 10, 1?18. http://dx.doi.org/10.1016/j.orcp.2015.12.004 Bonsi, M. L. K., Osuji, P. O., Tuah, A. K., Umunna, N.N. (1995). Vernonia amygdalina as a supplement to teff straw (Eragrostis tef) fed to Ethiopian Menz sheep. Agrofor. Syst., 31(3), 229?241. http://dx.doi.org/10.1007/BF00712076 Bordia, A., Verma, S. K. (1998). Effect of Celastrus paniculatus wild oil (Bravobol) on blood lipids in patients of coronary. Antiseptic, 95(4), 112?114. Charradi, K., Elkahoui, S., Karkouch, I., Limama, F., Ben Hassine, F., El May, M. V. (2014) Protective effect of grape seed and skin extract against high-fat-diet-induced liver steatosis and zinc depletion in rat. Dig. Dis. Sci., 59(8), 1768?1778. http://dx.doi.org/10.1007/s10620-014-3128-0 Chukwuonye, I. I., Chuku, A., John, C., Ohagwu, K. A.,Imoh, M. E., Isa, S. E., ..., Oviasu, E. (2013a). Prevalence of overweight and obesity in adult Nigerians ? a systematic review. Diab. Metab. Syndr. Obes. Targets Therap., 6, 43?47. http://dx.doi.org/10.2147/DMSO.S38626 Chukwuonye, I. I., Chuku, A., Okpechi, I. G., Onyeonoro,U. U., Madukwe, O. O., Okafor, G. O. C., Ogah, O. S. (2013b). Socioeconomic status and obesity in Abia State, South East Nigeria. Diab. Metab. Syndr. Obesit. Targets Therap., 6, 371?378. https://doi.org/10.2147/DMSO.S44426 Cromwell, W. C., Otvos, J. D. (2004). Low-density lipoprotein particles number and risk for cardiovascular disease. Curr. Atheroscl. Rep., 6, 381?387. http://dx.doi.org/10.1007/s11883-004-0050-5 D?Orazio, P., Burnett, R. W., Fogh-Andersen, N., Jacobs, E., Kuwa, K., Kulpmann, W. R., ?, Okorodudu, A. O. (2005). Approved International Federation of Clinical Chemistry (IFCC) recommendation on reporting results for blood glucose. Clin. Chem., 51(9), 1573?1576. http://dx.doi.org/10.1373/clinchem.2005.051979 Egedigwe, C. A. (2010). Effect of dietary incorporation of Vernonia amygdalina and Vernonia colorata on blood lipid profile and relative organ weights in Albino rats. M.Sc. Dissertation in Department of Biochemistry, MOUAU, Nigeria. Egedigwe, C. A. (2015). Evaluation of possible body fat regulatory mechanisms of crude extracts and fractions from leaves of Vernonia amygdalina in Wistar rats. Ph.D. Dissertation in the Department of Biochemistry, MOUAU, Nigeria. Egedigwe, C. A., Ijeh, I. I. (2010a). Body and organ weight changes following dietary incorporation of Vernonia colorata and Vernonia amygdalina Del in albino rats. Niger. J. Nutr. Sci., 31(2), 58?61. http://dx.doi.org/10.4314/njns.v31i2.63917 Egedigwe, C. A., Ijeh, I. I. (2010b). Lipid changes in albino rats fed diets incorporating Vernonia amygdalina Del leaves. Niger. J. Biochem. Mol. Biol., 25(2), 105?110. Egedigwe, C. A., Ejike, C. E. C. C., Ijeh, I. I., Herbert, U., Onwuka, G. I., Asumugha, V. U. (2016a). Anti-obesity potentials of aqueous and methanol extracts of Vernonia amygdalina Del. leaves in high-fat diet fed rats. Afr. J. Trad. Compl. Altern. Med., 13(2), 86?93. http://dx.doi.org/10.4314/ajtcam.v13i2.11 Egedigwe, C. A., Ijeh, I. I., Okafor, P. N., Ejike, Ch. E. C.C. (2016b). Aqueous and methanol extracts of Vernonia amygdalina leaves exert their anti-obesity effects through the modulation of appetite-regulatory hormones. Pharm. Biol., 54, 12, 1?6. http://dx.doi.org/10.1080/13880209.2016.1216135 Farombi, E. O., Owoeye, O. (2011). Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid. Int. J. Environ. Res. Public Health, 8(6), 2533?2555. http://dx.doi.org/10.3390/ijerph8062533 Francis, G., Kerem, Z., Makkar, H. P. Becker, K. (2002). The biological action of saponins in animal systems: a review. Brit. J. Nutr., 88, 6, 587?605. http://dx.doi.org/10.1079/BJN2002725 Friedewald, W. T., Levy, R. I., Frederickson, D. S. (1972). Estimation of the concentration of LDL cholesterol in plasma, without the use of the preparative ultracentrifuge. Clin. Chem., 18, 499?502. PMID: 4337382. Ghibaudi, L., Cook, J., Farley, C., van Heek, M., Hwa, J. J. (2002). Fat intake affects adiposity, comorbidity factors and energy metabolism of Sprague-Dawley rats. Obesity Res., 10(9), 956?963. http://dx.doi.org/10.1038/oby.2002.130 Han, L. K., Kimura, Y., Okuda, H. (2005a). Antiobesity effects of natural products. Stud. Nat. Prod. Chem., 30, 79?109.Han, L. K., Zheng, Y. N., Yoshikawa, M., Okuda, H., Kimura, Y. (2005b). Antiobesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes. BMC Compl. Altern. Med., 5(9), 1?10. http://dx.doi.org/10.1186/1472-6882-5-9 Han L. K., Zheng, Y. N., Xu, B. J., Okuda, H., Kimura, Y. (2002). Saponins from Platycodi radix ameliorate high-fat-diet-induced obesity in mice. J. Nutr., 132, 2241? 2245. PMID: 12163669. Harrold, J. A., Williams, G., Widdowson, P. S. (2000). Early leptin response to a palatable diet predicts dietary obesity in rats: Key role of melanocortin-4 receptors in the ventromedial hypothalamic nucleus. J. Neurochem., 74, 1224?1228. Hasani-Ranjbar, S., Larijani, B., Abdollahi, M. (2008). A systematic review of Iranian medicinal plants useful in diabetes mellitus. Arch. Med. Sci., 4, 285?292. Ibrahim, N. D. G., Abdurahman, G., Ibrahim, E. M. (2000). Histological studies on the effects of chronic feeding of Vernonia amygdalina Del. leaves on rats. Niger. J. Surgery Res., 2, 68?74. http://dx.doi.org/10.4314/njsr. v2i2.12188 Igile, G., Oleszek, W., Burda, S., Jurzysta, M. (1995). Nutritional assessment of Vernonia amygdalina leaves in growing mice. J. Agric. Food Chem., 43, 2162?2166. Ijeh, I. I., Egedigwe, A. C., Inyang, E. I., Emmanuel, G. (2014). Hypolipidaemic effects and body weight changes of male Wistar rats administered crude saponin extracts from Vernonia amydalina and Vernonia colorata leaves. Niger. J. Biochem. Molecular Biol., 29(1), 35?43. Ijeh, I. I., Amadi, I. P., Ejike, C. E. C. C. (2013). Improvement of glucose tolerance in rats fed with diets containing Vernonia amygdalina. Biokemistri, 25(1), 1?5. Ijeh, I. I., Akomas, S. C. (2005). Effect of oral administration of ethanolic extract of Vernonia amygdalina on the exocrine functions in weanling rabbits. Proceedings of the 30th Annual Conference of the Nigerian Society for Animal Production, 30. Ijeh, I. I., Ejike, C. E. C. C. (2011). Current perspectives on the medicinal potentials of Vernonia amygdalina Del. J. Med. Plants Res., 5, 1051?1061. Ijeh, I. I., Obidoa, O. (2001). Effect of dietary incorporation of two varieties of Vernonia amygdalina on mean relative organ weight of weanling rabbits. Niger. J. Biochem. Molec. Biol., 16, 13. Ijeh, I. I., Nwugo,V. O., Obidoa, O. (1996). Comparative studies on the nutritive, phytochemical and antimicrobial properties of two varieties of Vernonia amygdalina. Plant Prod. Res. Commun., 1, 71?75. Jenkin, D. J. A., Jenkin, A. L., Wolever, T. M. S., Rao, A. V., Thompson, L. U. (1986). Fibre and stang foods: gut function and implication in disease. Am. J. Gastroenter., 81, 920?930. Karu, N., Reifen, R., Kerem, Z. (2007). Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor. J. Agric. Food Chem., 55, 2824?2828. http://dx.doi.org/10.1021/jf0628025 Komolafe, K., Olaleye, M. T., Fasan, T. I., Elekofehinti, O. O., Saliu, J. A., Akindahunsi, A. A. (2013). Lowering effect of Parkia biglobosa leaf saponins in Triton-X1339-induced hyperlipidemic rats. Res. J. Pharm. Biol. Chem. Sci., 4(1), 576?585. Kritchevsky, D. (1977). Dietary fibre and other dietary factors in hypercholesterolemia. Am. J. Clin. Nutr., 30, 979?984. Lee, M. O. (1929). Determination of the surface area of the white rat with its application to the expression of metabolic results. Am. J. Physiol., 89(1), 24?33. Lee, S. O., Simons, A. L., Murphy, P. A., Hendrich, S. (2005). Soya saponins lowered plasma cholesterol and increased fecal bile acids in female golden Syrian hamsters. Exp. Biol. Med., 230, 472?478. PMID: 15985622. Lopes-Virella, M. F., Stone, P., Ellis, S. (1977). Cholesterol determination in high density lipoprotein separated by three different methods. Clin. Chem., 23, 882 PMID:192488. Mistry, K. G., Deshpande, S. S., Shah, G. B., Gohil, P. V. (2011). Effect of sarpogrelate in high-fat-diet-induced obesity in rats. Asian J. Pharm. Biol. Res., 441?446. Mohan, H. (2007). Pathology practical book (pp. 126?127).2nd ed. New Delhi: Jaypee Brothers Publ. Moro, C. O., Basile, G. (2000). Obesity and medicinal plants. Fitoterapia, 71, S73?S82. PMID: 10930716. Nwanjo, H. U. (2005). Efficacy of aqueous leaf extract of Vernonia amygdalina on plasma lipoproteins and oxidative status in diabetic rat model. Nigeria J. Physiol. Sci., 20(1?2), 39?42. NIH Publications 80?23 revised (1996). Guide for the care and use of laboratory animals. Betheseda, USA: Office of Science and Health Reports. MD 20205. Oakenfull, D. G., Sidhu, G. S. (1989). Saponins. In P. R. Cheeke (ed.), Toxicants of plant origin. 2. Glycosides (pp. 97?143). Boca Raton, Florida: CRC Press. Ong, K. W., Hsu, A., Song, L., Huang, D., Tan, B. K. (2011). Polyphenolsrich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats. J. Ethnopharm., 133(2), 598?607. http://dx.doi.org/10.1016/j.jep.2010.10.046 Ong, S. L., Nalamolu, K. R., Lai, H. Y. (2017). Potential lipid- lowering effects of Eleusine indica (L.) Gaertn. extract on high-fat-diet-induced hyperlipidemic rats. Pharmacogn. Mag., 13, 49, 1?9. http://dx.doi.org/10.4103/0973-1296.203986 Rayalam, S., Della-Fera, M. A., Baile, C. A. (2008). Phytochemicals and regulation of the adipocyte life cycle. J. Nutr. Biochem., 19, 717?726. http://dx.doi. org/10.1016/j.jnutbio.2007.12.007 Singh, D. (2006). Principles and techniques in histology micrograph and photomicrography. 2nd ed. (pp. 19?54). New Delhi, India: CBS Publ. Distrib. Teguia, A., Tchoumboue, J., Mayaka, B. T., Tnakou, C. M. (1993). The growth of broiler chickens as affected by the replacement of graded levels of maize by sweet potato leaves (Ipomoea batatas) or Ndole (Vernonia spp.) in the finisher diet. Anim. Feed Sci. Techn., 40, 233?237. Thielecke, F., Boschmann, M. (2009). The potential role of green tea catechins in the prevention of the metabolic syndrome ? A review. Phytochemistry, 70, 11?24. http://dx.doi.org/10.1016/j.phytochem.2008.11.011 Tietz, N. W. (1990). Clinical guide to Laboratory tests. 2nd ed. (pp. 554?556). Philadelphia, USA: WB Saunders Comp. Topping, D. L., Storer, G. B., Calvert, G. G. (1980). Effects of dietary saponins on faecal bile acids and neutral sterols, plasma lipid and lipid turnover in the pig. Am. J. Clin. Nutr., 33(4), 783?786. PMID: 7361696. WHO (1999). Radix ginseng. In WHO monographs on selected medicinal plants (pp. 168?162). Geneva: World Health Organization. WHO (2012). World health statistics. Geneva: WHO. Retrieved from: http://www.who.int/gho/publications/ world_health_statistics/EN_WHS2012_Full.pdf. Wolfram, S., Wang Y., Thielecke, F. (2006). Antibesity effects of green tea: from bedside to bench. Molec. Nutr. Food Res., 50, 176?187. http://dx.doi.org/10.1002/mnfr.200500102 Yokozawa, T., Cho, E. J., Sasaki, S., Satoh, A., Okamoto, T., Sei, Y. (2006). The protective role of Chinese prescription Kangenkaryu extract on diet-induced hyper- cholesterolemia in rats. Biol. Pharm. Bull., 29, 760?765. Yoshizumi, K., Hirano, K., Ando, H., Hirai, Y., Ida, Y., Tsu- ji, T., ..., Terao, J. (2006). Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase. J. Agric. Food Chem., 54,335?341. Yun, J. W. (2010). Possible anti-obesity therapeutics from nature ? A review. Phytochem. J., 71, 1625?1641. http://dx.doi.org/10.1016/j.phytochem.2010.07.011 Zhao, H. L., Harding, S. V., Marinangeli, C. P., Kim, Y. S., Jones, P. J. (2008). Hypocholesterolemic and anti-obesity effects of saponins from Platycodongrandiflorum inhamsters fed atherogenic diets. J. Food Sci., 73(8), 195?200. http://dx.doi.org/10.1111/j.1750-3841.2008.00915.x Vernonia amygdalina, antiobesity, high-fat diet, lipid profile, adiposity 10.17306/J.AFS.0504

ORIGINAL_ARTICLE 443-49 en 2017 16 4 Anna Huta-Osiecka Zbigniew Kasprzak Krystian Wochna Alicja Nowak Al-Eisa, E. S., Alghadir, A. H., Gabr, S. A. (2016). Correlaion between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults. Clin. Interv. Aging., 4, 11, 513?522. http://dx.doi.org/10.2147/CIA.S102892 Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft,A. J., Morley, J. E., ..., Boirie, Y. (2013). Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. JAMDA, 14, 542?559. Bonjour, J. P., Brandolini-Bunlon, M., Boirie, Y., Morel-Laporte, F., Braesco, V., Berti?re, M. C., Souberbielle, J.C. (2008). Inhibition of bone turnover by milk intake in postmenopausal women. Br. J. Nutr., 100(4), 866?874. Bonjour, J. P., Chevalley, T.(2014). Pubertal timing, bone acquisition, and risk of fracture throughout life. Endocr. Rev., 35(5), 820-847. Bonjour, J. P., Benoit, V., Atkin, S., Walrand, S. (2015). Fortification of yogurts with vitamin D and calcium enhances the inhibition of serum parathyroid hormone and bone resorption markers: a double blind randomized controlled trial in women over 60 living in a community dwelling home. J. Nutr. Health Aging., 19(5), 563?569. http://dx.doi.org/10.1007/s12603-015-0498-8 Bonjour, J. P. (2016). The dietary protein, IGF-I, skeletal health axis. Horm. Mol. Biol. Clin. Investig., 28(1), 39? 53. http://dx.doi.org/10.1515/hmbci-2016-0003 Cashman, K. D., Ritz, C., Kiely, M. (2017). Odin Collaborators. Improved dietary guidelines for vitamin D: application of individual participant data (IPD)-level meta-regression analyses. Nutrients, 9(5), 469. http://dx.doi. org/10.3390/nu9050469 Charzewska, J., Rogalska-Niedźwiedź, M., Jajszczyk, B., Chojnowska, Z., Dubicz, M. (1997). Metody oceny sposobu żywienia na poziomie indywidualnym oraz instrukcja sposobu przeprowadzania wywiadu o spożyciu z ostatnich 24 godzin poprzedzających badanie. Projekt zamawiany: ?Studia nad założeniami do polityki wyżywienia w Polsce? [Methods for assessing the individual?s diet as well as instructions on how to conduct an intake interview from the last 24 hours preceding the study. Project commissioned: ?Studies on assumptions for food policy in Poland?]. Warszawa: Instytut Żywności i Żywienia [in Polish]. Cordeiro, A., Santos, A., Bernardes, M., Ramalho, A., Martins, M. J. (2017). Vitamin D metabolism in human adipose tissue: could it explain low vitamin D status in obesity? Horm. Mol. Biol. Clin. Investig. pii: /j/hmbci. aheadof-print/hmbci-2017-0003/hmbci-2017-0003. xml. http://dx.doi.org/10.1515/hmbci-2017-0003 Curtis, E., Litwic, A., Cooper, C., Dennison, E. (2015). Determinants of muscle and bone aging. J. Cell Physiol., 230(11), 2618?2625. http://dx.doi.org/10.1002/jcp.25001 Frassetto, L. A., Todd, K. M., Morris, R. C., Sebastian, A. (2000). Worldwide incidence of hip fracture in elderly women: relation to consumption of animal and vegetable foods. J. Gerontol. A. Biol. Sci. Med. Sci., 55(10), M585?M592. Holick, M. F., Siris, E. S., Binkley, N., Beard, M. K., Khan,A., Katzer, J. T., ..., de Papp, A. E. (2005). Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J. Clin. Endocrinol. Metab., 90(6), 3215?3224. Holick, M. F., Chen, T. C. (2008). Vitamin D deficiency: a worldwide problem with health consequences. Am. J. Clin. Nutr., 87(4), 1080S?1086S. Holick, M. F., Binkleym, N. C., Bischoff-Ferrari, H. A., Gordon, C. M., Hanley, D. A., Heaney, R. P., ..., Weaver,C. M. (2012). Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J. Clin. Endocrinol. Metab., 97(4), 1153?1158. http://dx.doi.org/10.1210/jc.2011-2601 Jarosz, M. (2012). Normy żywienia dla populacji polskiej ? nowelizacja [Standards of nutrition for the Poland population ? amendment]. Warszawa: Instytut Żywności i Żywienia [in Polish]. Jungert, A., Spinneker, A., Nagel, A., Neuhäuser-Berthold,M. (2014). Dietary intake and main food sources of vitamin D as a function of age, sex, vitamin D status, body composition, and income in an elderly German cohort. Food Nutr. Res., 58. http://dx.doi.org/10.3402/fnr.v58.23632 Knapik, J. J, Reynolds, K., Hoedebecke, K. L. (2017). Stress fractures: etiology, epidemiology, diagnosis, treatment, and prevention. J. Spec. Oper. Med., 17(2), 120?130. Kwon, S. J., Ha, Y. C., Park, Y. (2017). High dietary sodium intake is associated with low bone mass in postmenopausal women: Korea National Health and Nutrition Examination Survey, 2008?2011. Osteop. Int., 28(4),1445?1452. http://dx.doi.org/10.1007/s00198-017-3904-8 Mostafa, W. Z., Hegazy, R. A. (2015) Vitamin D and theskin: Focus on a complex relationship: A review. J. Adv. Res., 6(6), 793?804. http://dx.doi.org/10.1016/j. jare.2014.01.011 Nakamura, K., Nashimoto, M., Hori, Y., Yamamoto, M. (2000). Serum 25-hydroxyvitamin D concentrations and related dietary factors in periand postmenopausal Japanese women. Am. J. Clin. Nutr., 71(5), 1161?1165. Płudowski, P., Karczmarewicz, E., Bayer, M., Carter G., Chlebna-Sokół, D., Czech-Kowalska, J., ..., Żmijewski,M. A. (2013). Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe ? recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol. Pol., 64(4), 319?327. Prentice, A., Schoenmakers, I., Laskey, M. A., de Bono, S., Ginty, F., Goldberg, G. R. (2006). Nutrition and bone growth and development. Proc. Nutr. Soc., 65(4), 348?360. Rejnmark, L. (2011). Effects of vitamin d on muscle funtion and performance: a review of evidence from randomized controlled trials. Ther. Adv. Chronic. Dis., 2(1), 25?37. http://dx.doi.org/10.1177/2040622310381934 Seeman, E. (2013). Age-and menopause-related bone loss compromise cortical and trabecular microstructure. J. Gerontol. A. Biol. Sci. Med. Sci., 68(10), 1218?1225. Sellmeyer, D. E., Stone, K. L., Sebastian, A., Cummings, S. R. (2001). A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Am. J. Clin. Nutr., 73, 118?122. Shams-White, M. M., Chung, M., Du, M., Fu, Z., Insogna,K. L., Karlsen, M. C., ..., Weaver, C. M. (2017). Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation. Am. J. Clin. Nutr., 105(6), 1528?1543. http://dx.doi.org/10.3945/ajcn.116.145110 Śmidowicz, A., Reguła, J. (2015). Dietary gender differences in terms of the risk of atherogenesis in Poland. Acta Sci. Pol. Technol. Aliment., 14(3), 257?267. http:// dx.doi.org/10.17306/J.AFS.2015.3.37 Torbergsen, A. C., Watne, L. O., Wyller, T. B., Frihagen, F., Str?ms?e, K., B?hmer, T., Mowe, M. (2017). Micronutrients and the risk of hip fracture: Casecontrol study. Clin. Nutr., 36(2), 438?443. http://dx.doi.org/10.1016/j.clnu.2015.12.014 Tylavsky, F. A., Spence, L. A., Harkness, L. (2008). The importance of calcium, potassium, and acid-base homeostasis in bone health and osteoporosis prevention. J. Nutr., 138, 1645?1655. Vimaleswaran, K. S., Berry, D. J., Lu, C., Tikkanen, E., Pilz, S., Hiraki, L.T., ..., Ohlsson, C. (2013). Causal relationship between obesity and vitamin D status: bidi- rectional mendelian randomization analysis of multiple cohorts. PLoS Med., 10. https://doi.org/10.1371/journal.pmed.1001383 Whiting, S. J., Kohrt, W. M., Warren, M. P., Kraenzlin,M. I., Bonjour, J. P. (2016). Food fortification for bone health in adulthood: a scoping review. Eur. J. Clin. Nutr., 70(10), 1099?1105. http://dx.doi.org/10.1038/ ejcn.2016.42 Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., Holick,M. F. (2000). Decreased bioavailability of vitamin D in obesity. Am. J. Clin. Nutr., 72(3), 690?693. women, menopause, nutrition, 25(OH)D 10.17306/J.AFS.0519

ORIGINAL_ARTICLE 451-460 en 2017 16 4 Ademola C. Famurewa Onyebuchi E. Nwankwo Abiola M. Folawiyo Emeka C. Igwe Michael A. Epete Odomero G. Ufebe Abbott, R. D., Wilson, P. W., Kannel, W. B., Castelli, W.P. (1988). High density lipoprotein cholesterol, total cholesterol screening and myocardial infarction. The Framingham Study. Arteriosclerosis, 8, 207?211. Abdullah, A., Shahrul, S., Chan, X. S., Noorhazliza, A. P., Khairunnisak, M., Qodriyah, H.M., ..., Kamsiah, J. (2010). Level of awareness amongst the general public regarding usage of repeatedly heated cooking oil in Kuala Lumpur, Malaysia. Inter. Med. J., 17(4), 310?311. Adam, S. K., Das, S., Jaarin, K. (2009). A detailed microscopic study of the changes in the aorta of experimental model of postmenopausal rats fed with repeatedly heated palm oil. Int. J. Exp. Pathol., 90(3), 321?327. Adam, S. K., Das, S., Soelaiman, I. N., Umar, N. A., Jaarin,K. (2008). Consumption of repeatedly heated soy oil increases serum parameters related to atherosclerosis in ovariectomized rats. Tohoku J. Exp. Med., 215(3), 219?226. Ajiboye, T. O., Aliyu, H., Tanimu, M. A., Muhammad, R. M., Ibitoye, O. B. (2016). Dioscoreophyllum cumminsii (Stapf) Diels leaves halt high-fructose induced metabolic syndrome: Hyperglycemia, insulin resistance, inflammation and oxidative stress. J. Ethnopharm., 192, 471?479. Akinnuga, A. M., Jeje, S. O., Bamidele, O., Amaku, E. E, Otogo, F. O., Sunday, V. E. (2014). Virgin coconut oil: Remedial effects on renal dysfunction in diabetic rats. Physiol. J., ID 495926. http://dx.doi. org/10.1155/2014/495926 Alladi, S., Khada, A., Shanmugan, M. (1989). Induction of hypercholesterolemia by simple soil protein with acetate generating amino acid. Nutr. Rep. Int., 40, 893?894. Ekor, M. (2014). The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol., 4, 177?186. http:// dx.doi.org/10.3389/fphar.2013.00177 Falade, A. O., Oboh, G., Ademiluyi, A. O., Odubanjo, O.V. (2015). Consumption of thermally oxidized palm oil diets alters biochemical indices in rats. BeniSuef Univ.J. Basic Appl. Sci., 4, 150?156. Famurewa, A. C., Ufebe, O. G., Egedigwe, C. A., Nwankwo,O. E., Obaje, G. S. (2017). Virgin coconut oil supplementation attenuates acute chemotherapy hepatotoxicity induced by anticancer drug methotrexate via inhibition of oxidative stress in rats. Biomed. Pharmacoth., 87, 437?442. Gasevic, D., Frohlich, J., Mancini, G. B., Lear, S. A. (2014). Clinical usefulness of lipid ratios to identify men and women with metabolic syndrome: A crosssectional study. Lipids Health Dis., 13, 159. Hur, S. J., Du, M., Nam, K., Williamson, M., Ahn, D. U. (2005). Effect of dietary fats on blood cholesterol and lipid and the development of atherosclerosis in rabbits. Nutr. Res., 25, 925?935. http://dx.doi.org/10.1016/j. nutres.2005.09.016 Ichihara, S. (2013). The pathological roles of environmental and redox stresses in cardiovascular diseases. Environ. Health Prev. Med., 18(3), 177?184. Jaarin, K., Kamisah, Y. (2012). Repeatedly heated vegetable oils and lipid peroxidation. In A. Catala (Ed.), Biochemistry, genetics and molecular biology (pp. 211?228). [Open access INTECH]. http://dx.doi. org/10.5772/46076 Jaarin, K., Mustafa, M. R., Leong, X.F. (2011). The effects of heated vegetable oils on blood pressure in rats. Clinics, 66(12), 2125?2132. http://dx.doi.org/10.1590/S1807-59322011001200020 Jaarin, K., Norliana, M., Kamisah, Y., Nursyafiza, M., Qodriyah, H. S. (2014). Potential role of virgin coconut oil in reducing cardiovascular risk factors. Exp. Clin. Cardiol., 20(8), 3399. Kalantar, M., Goudarzi, M., Khodayar, M. J., Babaei, J., Foruozandeh, H., Bakhtiari, N., Alidadi, H. (2016). Protective effects of the hydroalcoholic extract of Capparis spinosa L. against cyclophosphamide-induced nephrotoxicity in mice. Jundishapur J. Nat. Pharm. Prod., 11(4), e37240. http://dx.doi.org/10.17795/jjnpp-37240 Kalantari, H., Hemmati, A. A., Bavarsad, N., Rezaie, A., Ahmadi, S. (2014). Effect of topical nanoliposomes of paromomycin on rat liver and kidney. Jundishapur J. Nat. Pharm. Prod., 9(4), e17565. Kamisah, Y., Periyah, V., Lee, K. T., Noor-Izwan, N., Nurul-Hamizah, A., Nurul-Iman, B. S., ?, Qodriyah, M. S. (2015). Cardioprotective effect of virgin coconut oil in heated palm oil dietinduced hypertensive rats. Pharm. Biol., 53, 9, 1243?1249. Laguerre, M., Lecomte, J., Villeneuve, P. (2007). Evaluation of the ability of antioxidants to counteract lipid oxidation: existing methods, new trends and challenges. Prog. Lipid. Res., 46(5), 244?282. Latha, P., Chaitanya, D., Rukkumani, R. (2010). Protective effect of Phyllanthus niruri on alcohol and heated sun-flower oil induced hyperlipidemia in Wistar rats. Toxicol. Mech. Meth., 20(8), 498?503. Marina, A. M., Che-Man, Y. B., Nazimah, S. A., Amin, I. (2009). Antioxidant capacity and phenolic acids of virgin coconut oil. Int. J. Food Sci. Nutr., 60(S2), 114?123. Mourya, P., Shukla, A., Rai, G., Lodhi, S. (2017). Hypoglycemic and hypolipidemic effects of ethanolic and aqueous extracts from Ziziphus oenoplia (L.) Mill on alloxannduced diabetic rats. Beni-Suef Univ. J. BasicAppl. Sci., 6, 1?9. Nair, S. S., Manalil, J. J., Ramavarma, S. K., Suseela, I. M., Thekkepatt, A., Raghavamenon, A. C. (2016). Virgin coconut oil supplementation ameliorates cyclophos- phamide-induced systemic toxicity in mice. Hum. Exp. Toxicol., 35(2), 205?212. National Research Council (1985). Guide for the care and the use of laboratory animals, 20 (pp. 85?123). Bethesda: National Institute of Health. Nevin, K. G., Rajamohan, T. (2004). Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation. Clin. Biochem., 37, 830?835. Nevin, K. G., Rajamohan, T. (2009). Wet and dry extraction of coconut oil: impact on lipid metabolic and antioxidant status in cholesterol coadministered rats. Can. J. Physiol. Pharmacol., 87, 610?616. Ng, C.Y., Leong, X.F., Masbah, N., Adam, S. K., Kamisah, Y., Jaarina, K. (2014). Heated vegetable oils and cardio- vascular disease risk factors. Vascul. Pharmacol., 61, 1?9. http://dx.doi.org/10.1016/j.vph.2014.02.004 Obembe, A. O., Owu, D. U., Okwari, O. O., Antai, A. B., Osim, E. E. (2011). Intestinal fluid and glucose transport in Wistar rats following chronic consumption of fresh or oxidized palm oil diet. ISRN Gastroenterology, ID 972838. http://dx.doi.org/10.5402/2011/972838 Osim, E. E., Owu, D. U., Etta, K. M. (1996). Arterial pressure and lipid profile in rats following chronic ingestion of palm oil diets. Afr. J. Med. Med. Sci., 25(4), 335?340. Otuechere, C. A., Madarikan, G., Simisola, T., Bankole, O., Osho, A. (2013). Virgin coconut oil protects against liver damage in albino rats challenged with the antifolate combination, trimethoprimsulfamethoxazole. J. Basic Clin. Physiol. Pharmacol. http://dx.doi.org/10.1515/ jbcpp-2013-0059 Owu, D. U., Osim, E. E., Ebong, P. E. (1998). Serum liver enzymes profile of Wistar rats following chronic consumption of fresh or oxidized palm oil diets. Acta Trop., 69(1), 65?73. Rashid, J. A., Das, S., Kamsiah, J., Qodriyah, H. M., Faizah,O. (2013). Effect of curcumin on aortic changes in ovariectomized rats fed with repeatedly heated soy oil: a preliminary electron microscopic study. Clin. Ter., 164(4), 307?313. Shastry, C. S., Ambalal, P. N., Himanshu, J., Aswathanarayana, B. J. (2011). Evaluation of effect of reused edible oils on vital organs of Wistar rats. Nitte Univ. J. Health Sci., 1(4), 10?15. Srivastava, S., Singh, M., George, J., Bhui, K., Saxena, A., Shukla, Y. (2010). Genotoxic and carcinogenic risks associated with the dietary consumption of repeatedly heated coconut oil. Br. J. Nutr., 104(9), 1343?1352. Srivastava, Y., Semwal, A. D., Majumdar, A. (2016). Quantitative and qualitative analysis of bioactive components present in virgin coconut oil. Cogent Food Agric., 2(1). ID 1164929. http://dx.doi.org/10.1080/23311932.2016.1164929 Srivastava, Y., Semwal, A. D., Swamy, M. S. (2013). Hypo-cholesterolemic effects of cold and hot extracted virgin coconut oil (VCO) in comparison to commercial coconut oil: evidence from a male Wistar albino rat model. Food Sci. Biotechnol., 22, 1501?1508. Subermaniam, K., Saad, Q. H., Das, S., Othman, F. (2014). Virgin coconut oil (VCO) decreases the level of malondialdehyde (mda) in the cardiac tissue of experimental spraguedawley rats fed with heated palm oil. J. Med. Bioeng., 3(2), 102?106. Xian, T. K., Omar, N. A., Ying, L. W., Hamzah, A., Raj, S., Jaarin, K., ?, Hussan, F. (2012). Reheated palm oil consumption and risk of atherosclerosis: evidence at ultrastructural level. Evid.Based Compl. Alter. Med., ID 828170. http://dx.doi.org/10.1155/2012/828170 Yen, P.L., Chen, B.H., Yang, F. L., Lu, Y.F. (2010). Effects of deepfrying oil on blood pressure and oxidative stress in spontaneously hypertensive and normotensive rats. Nutrition, 26, 331?336. Zhang, Q., Saleh, A. S., Chen, J., Shen, Q. (2012). Chemical alterations taken place during deep-fat frying based on certain reaction products: a review. Chem. Phys. Lipids, 165(6), 662?681. virgin coconut oil, palm kernel oil, atherogenic indices, hyperlipidemia 10.17306/J.AFS.0513