original articleIssue 16 (3) 2017 pp. 345-354
Ewa Sapiejka1, Patrycja Krzyżanowska2, Dariusz Walkowiak3, Ewa Wenska-Chyży2, Mariusz Szczepanik2, Szczepan Cofta4, Andrzej Pogorzelski5, Wojciech Skorupa6, Jarosław Walkowiak2
2Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland
3Department of Organization and Management in Health Care, Poznan University of Medical Sciences, Poland
4University Hospital of Lord?s Transfiguration, Partner of Poznan University of Medical Sciences, Poland
5Department of Pulmonology and Cystic Fibrosis, Institute of Tuberculosis and Lung Diseases, Rabka-Zdrój, Poland
6I Department of Lung Diseases, National Institute for Tuberculosis and Lung Diseases, Warsaw, Poland
Vitamin A status and its determinants in patients with cystic fibrosis
Background. Routine administration of vitamin A, recommended in CF patients, can help to prevent its deficiency. However, high vitamin A supplementation may lead to its excessive level and possible toxicity. Therefore, the aim of the present study was to assess the status of vitamin A and the determinants of its body resources in CF patients.
Material and methods. In 196 CF patients aged from 4 months to 47 years, the following parameters were analysed: nutritional status (standardized body weight and height, serum albumin concentration) and clinical expression of disease (lung function − spirometry; biochemical markers of liver function − ALT, AST, GGT; respiratory tract colonization by Pseudomonas aeruginosa; diabetes; cirrhosis, non-cirrhotic liver disease; exocrine pancreatic function − fecal elastase-1 concentration; blood clotting – INR and vitamin A supplementation).
Results. Median vitamin A concentration in the study group was 383.0 ng/ml (1st–3rd quartile: 316.5–457.0). Vitamin A deficiency was found in 32 (16.3%) subjects studied. Vitamin A concentrations above the reference range were observed only in 3 (1.5%) CF patients. CF patients with vitamin A deficiency were significantly older and had lower values of FEV1 compared to CF subjects with normal vitamin A status. Moreover, vitamin A deficiency occurred more frequently in CF patients with diabetes, Pseudomonas aeruginosa colo- nization, worse lung function and in those without vitamin A supplementation. However, in multiple linear regression analyses, none of the independent variables was documented to be important for predicting vita- min A status.
Conclusions. Vitamin A body resources in CF patients are mostly normal. Moreover, there are no good de- terminants of vitamin A status in these patients. Further studies targeted at exploring potential toxicity and deficiencies of vitamin A in CF patients are needed.
Keywords: retinol, fat-soluble vitamins, pancreatic disease, liver cirrhosis, high-performance liquid chromatography
|MLA||Sapiejka, Ewa, et al. "Vitamin A status and its determinants in patients with cystic fibrosis." Acta Sci.Pol. Technol. Aliment. 16.3 (2017): 345-354. http://dx.doi.org/10.17306/J.AFS.0473|
|APA||Sapiejka E., Krzyżanowska P., Walkowiak D., Wenska-Chyży E., Szczepanik M., Cofta S., Pogorzelski A., Skorupa W., Walkowiak J. (2017). Vitamin A status and its determinants in patients with cystic fibrosis. Acta Sci.Pol. Technol. Aliment. 16 (3), 345-354 http://dx.doi.org/10.17306/J.AFS.0473|
|ISO 690||SAPIEJKA, Ewa, et al. Vitamin A status and its determinants in patients with cystic fibrosis. Acta Sci.Pol. Technol. Aliment., 2017, 16.3: 345-354. http://dx.doi.org/10.17306/J.AFS.0473|