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original articleIssue 16 (4) 2017 pp. 431-442

Chima A. Ekeleme-Egedigwe1, Ifeoma I. Ijeh2, Polycarp N. Okafor2

1Department of Chemistry/Biochemistry, Federal University Ndufu Alike Ikwo, Nigeria
2
Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture Umudike, Nigeria

Modulatory effects of dietary supplementation by Vernonia amygdalina on high-fat-diet-induced obesity in Wistar rats

Abstract

Background. Obesity is a growing public health problem arising from energy imbalance. The effect of 10% dietary incorporation of Vernonia amygdalina (VA) leaves into high-fat diets on some biological markers of adiposity and dyslipidaemia was investigated.

Methods. Experimental diets consisted of the following – CD (control diet); HFD (high-fat diet); and HFD- VA (HFD containing 10% Vernonia amygdalina leaves) supplementation. Fifteen male Wistar rats were randomly divided into three groups of five animals each. After twelve weeks of feeding, serum lipid profile, blood glucose concentrations, body weight, adiposity index, feed intake, fecal loss and relative organ weight were investigated.

Results. Vernonia amygdalina (VA) inhibited HFD-induced weight gain and adiposity in rats. HFD-induced obese rats showed a significant increase in the levels of serum TG and TC compared to rats on a normal diet. However, the levels of serum TG, TC, LDL-C in HFDVA rats reduced significantly relative to the levels in HFD rats. Our results indicate that HFDVA reversed fatty infiltration leading to decreased body weight and fat tissue mass in the rats.

Conclusion. These results suggested that incorporation of Vernonia amygdalina into high-fat diets may have therapeutic potentials for obesity and related metabolic disorders. Further studies to explore its possibility as an alternative pharmacologic agent to treat obesity are warranted.

Keywords: Vernonia amygdalina, antiobesity, high-fat diet, lipid profile, adiposity
pub/.pdf Full text available in english in Adobe Acrobat format:
http://www.food.actapol.net/issue4/volume/8_4_2017.pdf

http://dx.doi.org/10.17306/J.AFS.0504

For citation:

MLA Ekeleme-Egedigwe, Chima A., et al. "Modulatory effects of dietary supplementation by Vernonia amygdalina on high-fat-diet-induced obesity in Wistar rats." Acta Sci.Pol. Technol. Aliment. 16.4 (2017): 431-442. http://dx.doi.org/10.17306/J.AFS.0504
APA Ekeleme-Egedigwe C. A., Ijeh I. I., Okafor P. N. (2017). Modulatory effects of dietary supplementation by Vernonia amygdalina on high-fat-diet-induced obesity in Wistar rats. Acta Sci.Pol. Technol. Aliment. 16 (4), 431-442 http://dx.doi.org/10.17306/J.AFS.0504
ISO 690 EKELEME-EGEDIGWE, Chima A., IJEH, Ifeoma I., OKAFOR, Polycarp N.. Modulatory effects of dietary supplementation by Vernonia amygdalina on high-fat-diet-induced obesity in Wistar rats. Acta Sci.Pol. Technol. Aliment., 2017, 16.4: 431-442. http://dx.doi.org/10.17306/J.AFS.0504