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original articleIssue 17 (3) 2018 pp. 219-226

Mohammad Nikkhahi1, Effat Souri1, Parisa Sarkhail2, Maryam Baeeri2, Negar Mohammadhosseini2

1Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS) Tehran, Iran
2
Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Iran

Evaluation of anti-tyrosinase activity of Allium ursinum extracts and their metal complexes

Abstract

Background. A. ursinum is found to contain high levels of some beneficial phenolic and poly phenolic compounds were found to be effective in scavenging DPPH radicals and tyroinase inhibition. The aim of this study was to evaluate the anti-tyrosinase and antioxidant activity of three different extracts from the ultrasound-assisted method and their metal complexes from A. ursinum to discover new candidates for food additives, cosmetic and pharmaceutical products.

Material and methods. Water, 70% ethanol and absolute ethanol extract of Allium ursinum and their man- ganese and zinc-complexes were characterized by FT-IR and UV-Vis spectra and their antioxidant and anti- tyrosinase activity determined using DPPH radical scavenging and mushroom tyrosinase assay.

Results. The antioxidant activity of the water extract was superior to other samples, while the 70% ethanol extract exhibited the highest anti-tyrosinase activity. Metal complex formation of the extracts led to a signifi- cantly lower antioxidant effect. The tyrosinase inhibition strongly related to the metal ion and extraction sol- vent. All the zinc complexes had lower anti-tyrosinase activity than their extracts, while the manganese com- plex of the water and absolute ethanol extracts exhibited higher anti-tyrosinase activity than related extracts. Conclusion. This study shows that Mn complex of A. ursinum extracts, based on the solvent extraction, could increase tyrosinase inhibition activity and could be a good candidate for intended cosmetic applications and food additives.

Keywords: Allium ursinum, antioxidant, anti-tyrosinase, metal complex, phenolic compounds
pub/.pdf Full text available in english in Adobe Acrobat format:
http://www.food.actapol.net/issue3/volume/3_3_2018.pdf

http://dx.doi.org/10.17306/J.AFS.0585

For citation:

MLA Nikkhahi, Mohammad, et al. "Evaluation of anti-tyrosinase activity of Allium ursinum extracts and their metal complexes." Acta Sci.Pol. Technol. Aliment. 17.3 (2018): 219-226. http://dx.doi.org/10.17306/J.AFS.0585
APA Nikkhahi M., Souri E., Sarkhail P., Baeeri M., Mohammadhosseini N. (2018). Evaluation of anti-tyrosinase activity of Allium ursinum extracts and their metal complexes. Acta Sci.Pol. Technol. Aliment. 17 (3), 219-226 http://dx.doi.org/10.17306/J.AFS.0585
ISO 690 NIKKHAHI, Mohammad, et al. Evaluation of anti-tyrosinase activity of Allium ursinum extracts and their metal complexes. Acta Sci.Pol. Technol. Aliment., 2018, 17.3: 219-226. http://dx.doi.org/10.17306/J.AFS.0585