Full text available in english in Adobe Acrobat format:https://www.food.actapol.net/volume21/issue1/9_1_2022.pdf
original articleIssue 21 (1) 2022 pp. 101-109
Livia Filla Nunes1, Flavia Tasmin Techera Antunes2, Alessandra Hubner de Souza2, Valesca de Souza Teixeira1, Elenir de Fátima Wiilland1, Jaqueline Nascimento Picada3, Lucimar Filot da Silva Brum1
1Department of Genetics and Applied Toxicology, Lutheran University of Brazil (ULBRA), Canoas, Rio Grande do Sul, Brazil
2Postgraduate Program in Cellular and Molecular Biology Applied to Health, Canoas, Rio Grande do Sul, Brazil
3Laboratory of Genetic Toxicology, Lutheran University of Brazil (ULBRA), Canoas, Rio Grande do Sul, Brazil
2Postgraduate Program in Cellular and Molecular Biology Applied to Health, Canoas, Rio Grande do Sul, Brazil
3Laboratory of Genetic Toxicology, Lutheran University of Brazil (ULBRA), Canoas, Rio Grande do Sul, Brazil
Anti-obesity, slimming, biochemical and genotoxic effects of Cordia ecalyculata in diet-induced obese rats
Abstract
Background. Overweight and obesity are associated with deaths and diseases worldwide. Cordia ecalyculata is a plant marketed as a slimmer.
Methods. The study evaluated the anti-obesity effects of the dry extract from C. ecalyculata in rats fed with a standard diet (STD) or cafeteria diet (CD) receiving the dry extract from C. ecalyculata at 500, 1000, and 2000 mg/kg for 40 days. Furthermore, it evaluated the slimming effect on diet-induced obese rats by the treatment with the same doses for 30 days. The bodyweight of the rats, as well as the intake of food, was measured. Blood samples were collected to determine the liver function (albumin, alanine transaminase (ALT), alkaline phosphatase (ALP), glucose), renal function (urea and creatinine), and lipid profile (cholesterol, triglycerides).
Results. The genotoxic effect in peripheral blood was assessed through the comet assay. A lower C. ecalyculata dose significantly prevented the weight gain in rats fed with STD and CD and decreased body weight and intake food of obese rats. The biochemical parameters were not altered, except to increase the serum albumin. Only the higher dose induced DNA damage when evaluated in rats fed with CD in the slimming evaluation model used.
Conclusion. These results reinforce the extract as an anti-obesity and slimming supplement.
Keywords: comet assay, Cordia ecalyculata, hepatic profile, obesity
Full text available in english in Adobe Acrobat format:https://www.food.actapol.net/volume21/issue1/9_1_2022.pdf
https://doi.org/10.17306/J.AFS.2022.0998
For citation:
| MLA | Nunes, Livia Filla, et al. "Anti-obesity, slimming, biochemical and genotoxic effects of Cordia ecalyculata in diet-induced obese rats." Acta Sci.Pol. Technol. Aliment. 21.1 (2022): 101-109. https://doi.org/10.17306/J.AFS.2022.0998 |
| APA | Nunes L. F., Techera Antunes F. T., de Souza A. H., de Souza Teixeira V., de Fátima Wiillandm E., Nascimento Picada J., da Silva Brum L. F. (2022). Anti-obesity, slimming, biochemical and genotoxic effects of Cordia ecalyculata in diet-induced obese rats. Acta Sci.Pol. Technol. Aliment. 21 (1), 101-109 https://doi.org/10.17306/J.AFS.2022.0998 |
| ISO 690 | NUNES, Livia Filla, et al. Anti-obesity, slimming, biochemical and genotoxic effects of Cordia ecalyculata in diet-induced obese rats. Acta Sci.Pol. Technol. Aliment., 2022, 21.1: 101-109. https://doi.org/10.17306/J.AFS.2022.0998 |