Full text available in english in Adobe Acrobat format:https://www.food.actapol.net/volume24/issue1/10_1_2025.pdf
original articleIssue 24 (1) 2025 pp. 145-156
Oznur Ece Durmaz Kursun1, Goknur Yalim2, Murside Ayse Demirel3, Fusun Erten4, Kazim Sahin5, Fatma Akar6
1Department of Pharmacology, Faculty of Pharmacy, Firat University, Elazig, Turkey
2Department of Medical Pharmacology, Faculty of Medicine, Yuksek Ihtisas University Ankara, Turkey
3Laboratory Animals Breeding and Experimental Research Centre, Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Gazi University, Ankara, Turkey
4Department of Veterinary Science, Pertek Sakine Genc Vocational School, Munzur University, Tunceli, Turkey
5Department of Animal Nutrition and Nutritional Disorders, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey
6Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey
2Department of Medical Pharmacology, Faculty of Medicine, Yuksek Ihtisas University Ankara, Turkey
3Laboratory Animals Breeding and Experimental Research Centre, Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Gazi University, Ankara, Turkey
4Department of Veterinary Science, Pertek Sakine Genc Vocational School, Munzur University, Tunceli, Turkey
5Department of Animal Nutrition and Nutritional Disorders, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey
6Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey
Effects of Lactobacillus plantarum on the Akt/eNOS cardiac pathway in rats with fructose-induced metabolic syndrome
Abstract
Background. This study investigated the effects of Lactobacillus plantarum supplementation on the Akt/eNOS pathway in the cardiac tissue of rats subjected to a fructose-rich diet, which induced metabolic syndrome.
Materials and methods. Twenty-two male Wistar albino rats were randomly assigned to three groups: (1) control, (2) fructose, and (3) fructose ± L. plantarum. Rats in the fructose group were administered a 20% fructose solution in their drinking water for 15 weeks. In the L. plantarum-treated group, the probiotic was administered via gastric gavage at a daily dose of 1×10⁹ CFU/mL/100 g during the final six weeks of the study.
Results. The administration of Lactobacillus plantarum resulted in a significant increase in the levels of Akt (p < 0.0001), IRS-1 (p = 0.0113), mTOR (p < 0.0001), eNOS (p < 0.0001), and SIRT1 (p = 0.0031) in the cardiac tissue of rats compared to the fructose group. Moreover, a marked reduction in iNOS, NF-κB, and TNF-α levels (p < 0.0001) was observed, highlighting the potential of L. plantarum to counteract the adverse effects of fructose consumption.
Conclusion. The findings of this study suggest that L. plantarum has the potential to reduce inflammation in the heart, enhance insulin sensitivity via the Akt/eNOS pathway, and protect against cardiovascular diseases associated with metabolic syndrome.
Keywords: metabolic syndrome, Lactobacillus plantarum, Akt, eNOS, fructose, insulin
Full text available in english in Adobe Acrobat format:https://www.food.actapol.net/volume24/issue1/10_1_2025.pdf
https://doi.org/10.17306/J.AFS.001309
For citation:
| MLA | Kursun, Oznur Ece Durmaz, et al. "Effects of Lactobacillus plantarum on the Akt/eNOS cardiac pathway in rats with fructose-induced metabolic syndrome." Acta Sci.Pol. Technol. Aliment. 24.1 (2025): 145-156. https://doi.org/10.17306/J.AFS.001309 |
| APA | Kursun O. E. D., Yalim G., Demirel M. A., Erten F., Sahin K., Akar F. (2025). Effects of Lactobacillus plantarum on the Akt/eNOS cardiac pathway in rats with fructose-induced metabolic syndrome. Acta Sci.Pol. Technol. Aliment. 24 (1), 145-156 https://doi.org/10.17306/J.AFS.001309 |
| ISO 690 | KURSUN, Oznur Ece Durmaz, et al. Effects of Lactobacillus plantarum on the Akt/eNOS cardiac pathway in rats with fructose-induced metabolic syndrome. Acta Sci.Pol. Technol. Aliment., 2025, 24.1: 145-156. https://doi.org/10.17306/J.AFS.001309 |